Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: Clinicopathological analysis of 27 patients

Masahiro Hagiwara, Katsuyoshi Takata, Yoshie Shimoyama, Kazuhito Yamamoto, Emiko Takahashi, Naoko Asano, Yuko Iwase, Yoshiko Okazaki, Yasuhiko Tamada, Tadashi Yoshino, Yasushi Tomita, Shigeo Nakamura

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Abstract

The objective of our study was to investigate the clinicopathological features of the currently ill-defined subtype of primary cutaneous T-cell lymphoma of unspecified type (CTCLU) with a cytotoxic phenotype and no Epstein-Barr virus (EBV) association. A series of 27 patients with CTCLU (median age 49.years; range 25-87 years; 18 men) was reviewed. Performance status scores above 1 (7%), clinical stages above 2 (15%), B symptoms (26%), extracutaneous involvement (30%), and a fatal course within 1.year of diagnosis (19%) were observed infrequently. The International Prognostic Index was high or high to intermediate in 11%, and the Prognostic Index for Peripheral T-cell Lymphoma unspecified was above group 2 in 22%. Notably, the rates of spontaneous regression and T-cell receptor gene rearrangements by polymerase chain reaction analysis were seen in 26 and 17% of our cases, respectively. Histologically, 22 patients had subcutaneous involvement of whom eight showed a lethal clinical course, and five patients without subcutaneous involvement were all survivors. Immunophenotypical and morphological features allowed us to subclassify our cases according to the following four categories: (1) epidermotropic CD8+ T-cell lymphoma (n = 5); (2) cutaneous γ/δ T-cell lymphoma (n = 8); (3) cutaneous α/β pleomorphic T-cell lymphoma (n = 8); and (4) cutaneous medium/large pleomorphic T-cell lymphoma, not otherwise specified (n = 6). All four of these groups of lymphomas exhibited a relatively favorable clinical course compared to previous reports. However, epidermotropic CD8+ T-cell lymphoma appeared to be unique with a higher ratio (80%) of spontaneous regression, a lower ratio (40%) of subcutaneous involvement, and a more favorable clinical course than the other three subcategories.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalCancer Science
Volume100
Issue number1
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hagiwara, M., Takata, K., Shimoyama, Y., Yamamoto, K., Takahashi, E., Asano, N., Iwase, Y., Okazaki, Y., Tamada, Y., Yoshino, T., Tomita, Y., & Nakamura, S. (2009). Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: Clinicopathological analysis of 27 patients. Cancer Science, 100(1), 33-41. https://doi.org/10.1111/j.1349-7006.2008.01000.x