Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: Clinicopathological analysis of 27 patients

Masahiro Hagiwara, Katsuyoshi Takata, Yoshie Shimoyama, Kazuhito Yamamoto, Emiko Takahashi, Naoko Asano, Yuko Iwase, Yoshiko Okazaki, Yasuhiko Tamada, Tadashi Yoshino, Yasushi Tomita, Shigeo Nakamura

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


The objective of our study was to investigate the clinicopathological features of the currently ill-defined subtype of primary cutaneous T-cell lymphoma of unspecified type (CTCLU) with a cytotoxic phenotype and no Epstein-Barr virus (EBV) association. A series of 27 patients with CTCLU (median age 49.years; range 25-87 years; 18 men) was reviewed. Performance status scores above 1 (7%), clinical stages above 2 (15%), B symptoms (26%), extracutaneous involvement (30%), and a fatal course within 1.year of diagnosis (19%) were observed infrequently. The International Prognostic Index was high or high to intermediate in 11%, and the Prognostic Index for Peripheral T-cell Lymphoma unspecified was above group 2 in 22%. Notably, the rates of spontaneous regression and T-cell receptor gene rearrangements by polymerase chain reaction analysis were seen in 26 and 17% of our cases, respectively. Histologically, 22 patients had subcutaneous involvement of whom eight showed a lethal clinical course, and five patients without subcutaneous involvement were all survivors. Immunophenotypical and morphological features allowed us to subclassify our cases according to the following four categories: (1) epidermotropic CD8+ T-cell lymphoma (n = 5); (2) cutaneous γ/δ T-cell lymphoma (n = 8); (3) cutaneous α/β pleomorphic T-cell lymphoma (n = 8); and (4) cutaneous medium/large pleomorphic T-cell lymphoma, not otherwise specified (n = 6). All four of these groups of lymphomas exhibited a relatively favorable clinical course compared to previous reports. However, epidermotropic CD8+ T-cell lymphoma appeared to be unique with a higher ratio (80%) of spontaneous regression, a lower ratio (40%) of subcutaneous involvement, and a more favorable clinical course than the other three subcategories.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalCancer Science
Issue number1
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: Clinicopathological analysis of 27 patients'. Together they form a unique fingerprint.

Cite this