Primary amyloidosis associated with IgD-lambda M-proteinemia

Shunichi Kimura, Ryota Iwatsuka, Takatoshi Aoki, Jun Odawara, Noboru Asada, Masayuki Yamakura, Masami Takeuchi, Kosei Matsue

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We describe here a case of primary AL amyloidosis associated with IgD monoclonal gammopathy of undetermined significance. A 73-year-old man was referred to our hospital with suspected multiple myeloma due to renal failure and urinary Bence Jones protein. Although serum electrophoresis revealed IgDlambda monoclonal protein, the bone marrow did not showed plasma cell proliferation. Systemic bone survey disclosed no lytic bone lesions. Because the patient had macroglossia and multiple ecchymosis in the face and neck, primary amyloidosis was suspected. Skin biopsy revealed extensive deposition of amyloid which was positively stained by Congo red dye. A diagnosis of primary AL amyloidosis associated with IgD monoclonal gammopathy was made. The patient was also complicated renal failure that eventually needed hemodialysis. To our knowledge, this is the first report of primary AL amyloidosis associated with IgD monoclonal gammopathy with undetermined significance.

Original languageEnglish
Pages (from-to)1555-1558
Number of pages4
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume48
Issue number12
Publication statusPublished - Dec 2007
Externally publishedYes

Fingerprint

Immunoglobulin D
Monoclonal Gammopathy of Undetermined Significance
Renal Insufficiency
Macroglossia
Bence Jones Protein
Ecchymosis
Bone and Bones
Congo Red
Paraproteinemias
Plasma Cells
Multiple Myeloma
Amyloid
Renal Dialysis
Electrophoresis
Coloring Agents
Neck
Bone Marrow
Cell Proliferation
Biopsy
Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kimura, S., Iwatsuka, R., Aoki, T., Odawara, J., Asada, N., Yamakura, M., ... Matsue, K. (2007). Primary amyloidosis associated with IgD-lambda M-proteinemia. [Rinshō ketsueki] The Japanese journal of clinical hematology, 48(12), 1555-1558.

Primary amyloidosis associated with IgD-lambda M-proteinemia. / Kimura, Shunichi; Iwatsuka, Ryota; Aoki, Takatoshi; Odawara, Jun; Asada, Noboru; Yamakura, Masayuki; Takeuchi, Masami; Matsue, Kosei.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 48, No. 12, 12.2007, p. 1555-1558.

Research output: Contribution to journalArticle

Kimura, S, Iwatsuka, R, Aoki, T, Odawara, J, Asada, N, Yamakura, M, Takeuchi, M & Matsue, K 2007, 'Primary amyloidosis associated with IgD-lambda M-proteinemia', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 48, no. 12, pp. 1555-1558.
Kimura S, Iwatsuka R, Aoki T, Odawara J, Asada N, Yamakura M et al. Primary amyloidosis associated with IgD-lambda M-proteinemia. [Rinshō ketsueki] The Japanese journal of clinical hematology. 2007 Dec;48(12):1555-1558.
Kimura, Shunichi ; Iwatsuka, Ryota ; Aoki, Takatoshi ; Odawara, Jun ; Asada, Noboru ; Yamakura, Masayuki ; Takeuchi, Masami ; Matsue, Kosei. / Primary amyloidosis associated with IgD-lambda M-proteinemia. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2007 ; Vol. 48, No. 12. pp. 1555-1558.
@article{3533b1938cdc45a19c235eb99f314b88,
title = "Primary amyloidosis associated with IgD-lambda M-proteinemia",
abstract = "We describe here a case of primary AL amyloidosis associated with IgD monoclonal gammopathy of undetermined significance. A 73-year-old man was referred to our hospital with suspected multiple myeloma due to renal failure and urinary Bence Jones protein. Although serum electrophoresis revealed IgDlambda monoclonal protein, the bone marrow did not showed plasma cell proliferation. Systemic bone survey disclosed no lytic bone lesions. Because the patient had macroglossia and multiple ecchymosis in the face and neck, primary amyloidosis was suspected. Skin biopsy revealed extensive deposition of amyloid which was positively stained by Congo red dye. A diagnosis of primary AL amyloidosis associated with IgD monoclonal gammopathy was made. The patient was also complicated renal failure that eventually needed hemodialysis. To our knowledge, this is the first report of primary AL amyloidosis associated with IgD monoclonal gammopathy with undetermined significance.",
author = "Shunichi Kimura and Ryota Iwatsuka and Takatoshi Aoki and Jun Odawara and Noboru Asada and Masayuki Yamakura and Masami Takeuchi and Kosei Matsue",
year = "2007",
month = "12",
language = "English",
volume = "48",
pages = "1555--1558",
journal = "[Rinsho ketsueki] The Japanese journal of clinical hematology",
issn = "0485-1439",
publisher = "Nihon Rinsho Ketsueki Gakkai/Japan Society of Clinical Hematology",
number = "12",

}

TY - JOUR

T1 - Primary amyloidosis associated with IgD-lambda M-proteinemia

AU - Kimura, Shunichi

AU - Iwatsuka, Ryota

AU - Aoki, Takatoshi

AU - Odawara, Jun

AU - Asada, Noboru

AU - Yamakura, Masayuki

AU - Takeuchi, Masami

AU - Matsue, Kosei

PY - 2007/12

Y1 - 2007/12

N2 - We describe here a case of primary AL amyloidosis associated with IgD monoclonal gammopathy of undetermined significance. A 73-year-old man was referred to our hospital with suspected multiple myeloma due to renal failure and urinary Bence Jones protein. Although serum electrophoresis revealed IgDlambda monoclonal protein, the bone marrow did not showed plasma cell proliferation. Systemic bone survey disclosed no lytic bone lesions. Because the patient had macroglossia and multiple ecchymosis in the face and neck, primary amyloidosis was suspected. Skin biopsy revealed extensive deposition of amyloid which was positively stained by Congo red dye. A diagnosis of primary AL amyloidosis associated with IgD monoclonal gammopathy was made. The patient was also complicated renal failure that eventually needed hemodialysis. To our knowledge, this is the first report of primary AL amyloidosis associated with IgD monoclonal gammopathy with undetermined significance.

AB - We describe here a case of primary AL amyloidosis associated with IgD monoclonal gammopathy of undetermined significance. A 73-year-old man was referred to our hospital with suspected multiple myeloma due to renal failure and urinary Bence Jones protein. Although serum electrophoresis revealed IgDlambda monoclonal protein, the bone marrow did not showed plasma cell proliferation. Systemic bone survey disclosed no lytic bone lesions. Because the patient had macroglossia and multiple ecchymosis in the face and neck, primary amyloidosis was suspected. Skin biopsy revealed extensive deposition of amyloid which was positively stained by Congo red dye. A diagnosis of primary AL amyloidosis associated with IgD monoclonal gammopathy was made. The patient was also complicated renal failure that eventually needed hemodialysis. To our knowledge, this is the first report of primary AL amyloidosis associated with IgD monoclonal gammopathy with undetermined significance.

UR - http://www.scopus.com/inward/record.url?scp=40349091622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40349091622&partnerID=8YFLogxK

M3 - Article

C2 - 18203516

AN - SCOPUS:40349091622

VL - 48

SP - 1555

EP - 1558

JO - [Rinsho ketsueki] The Japanese journal of clinical hematology

JF - [Rinsho ketsueki] The Japanese journal of clinical hematology

SN - 0485-1439

IS - 12

ER -