Primary alkylboronic acids as highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids

Risa Yamashita, Akira Sakakura, Kazuaki Ishihara

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Abstract

Primary alkylboronic acids such as methylboronic acid and butylboronic acid are highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids. The catalytic activities of these primary alkylboronic acids are much higher than those of the previously reported arylboronic acids. The present method was easily applied to a large-scale synthesis, and 14 g of an amide was obtained in a single reaction.

Original languageEnglish
Pages (from-to)3654-3657
Number of pages4
JournalOrganic Letters
Volume15
Issue number14
DOIs
Publication statusPublished - Jul 19 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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