Primary alkylboronic acids as highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids

Risa Yamashita, Akira Sakakura, Kazuaki Ishihara

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Primary alkylboronic acids such as methylboronic acid and butylboronic acid are highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids. The catalytic activities of these primary alkylboronic acids are much higher than those of the previously reported arylboronic acids. The present method was easily applied to a large-scale synthesis, and 14 g of an amide was obtained in a single reaction.

Original languageEnglish
Pages (from-to)3654-3657
Number of pages4
JournalOrganic Letters
Volume15
Issue number14
DOIs
Publication statusPublished - Jul 19 2013

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Amides
amides
Condensation
condensation
catalysts
acids
Catalysts
Acids
Catalyst activity
catalytic activity
synthesis

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Primary alkylboronic acids as highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids. / Yamashita, Risa; Sakakura, Akira; Ishihara, Kazuaki.

In: Organic Letters, Vol. 15, No. 14, 19.07.2013, p. 3654-3657.

Research output: Contribution to journalArticle

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