Abstract
Introduction. Gastric tumors in patients affected by neurofibromatosis type 1 are usually carcinoids or stromal tumors, and rarely adenocarcinomas. Case presentation. We report a case of an adenocarcinoma of the stomach in a 53-year-old Japanese man with neurofibromatosis type 1. An abdominal computed tomography scan and ultrasonography showed tumors in his liver. Gastric fibroscopy revealed a Borrmann type III tumor on his cardia that had spread to his esophagus and was highly suspicious for malignancy. Multiple biopsies showed an adenocarcinoma of the stomach, which was evaluated as gastric cancer, stage IV. Chemotherapy with TS-1 was performed. Our patient died four weeks after initial admission. Histological examination of a liver needle biopsy showed metastatic adenocarcinoma in his liver. Conclusion: To the best of our knowledge, high serum levels of -fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 72-4, resulting from gastric adenocarcinoma, have not been reported previously in a patient with neurofibromatosis type 1. We report this rare case along with a review of the literature.
| Original language | English |
|---|---|
| Article number | 521 |
| Journal | Journal of Medical Case Reports |
| Volume | 5 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Medicine(all)
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Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers : A case report. / Kato, Kazuya; Nagase, Atsushi; Onodera, Kazuhiko; Matsuda, Minoru; Iwasaki, Yoshiaki; Kato, Yurina; Kato, Kimitaka; Kawakami, Takako; Taniguchi, Masahiko; Furukawa, Hiroyuki.
In: Journal of Medical Case Reports, Vol. 5, 521, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers
T2 - A case report
AU - Kato, Kazuya
AU - Nagase, Atsushi
AU - Onodera, Kazuhiko
AU - Matsuda, Minoru
AU - Iwasaki, Yoshiaki
AU - Kato, Yurina
AU - Kato, Kimitaka
AU - Kawakami, Takako
AU - Taniguchi, Masahiko
AU - Furukawa, Hiroyuki
PY - 2011
Y1 - 2011
N2 - Introduction. Gastric tumors in patients affected by neurofibromatosis type 1 are usually carcinoids or stromal tumors, and rarely adenocarcinomas. Case presentation. We report a case of an adenocarcinoma of the stomach in a 53-year-old Japanese man with neurofibromatosis type 1. An abdominal computed tomography scan and ultrasonography showed tumors in his liver. Gastric fibroscopy revealed a Borrmann type III tumor on his cardia that had spread to his esophagus and was highly suspicious for malignancy. Multiple biopsies showed an adenocarcinoma of the stomach, which was evaluated as gastric cancer, stage IV. Chemotherapy with TS-1 was performed. Our patient died four weeks after initial admission. Histological examination of a liver needle biopsy showed metastatic adenocarcinoma in his liver. Conclusion: To the best of our knowledge, high serum levels of -fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 72-4, resulting from gastric adenocarcinoma, have not been reported previously in a patient with neurofibromatosis type 1. We report this rare case along with a review of the literature.
AB - Introduction. Gastric tumors in patients affected by neurofibromatosis type 1 are usually carcinoids or stromal tumors, and rarely adenocarcinomas. Case presentation. We report a case of an adenocarcinoma of the stomach in a 53-year-old Japanese man with neurofibromatosis type 1. An abdominal computed tomography scan and ultrasonography showed tumors in his liver. Gastric fibroscopy revealed a Borrmann type III tumor on his cardia that had spread to his esophagus and was highly suspicious for malignancy. Multiple biopsies showed an adenocarcinoma of the stomach, which was evaluated as gastric cancer, stage IV. Chemotherapy with TS-1 was performed. Our patient died four weeks after initial admission. Histological examination of a liver needle biopsy showed metastatic adenocarcinoma in his liver. Conclusion: To the best of our knowledge, high serum levels of -fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 72-4, resulting from gastric adenocarcinoma, have not been reported previously in a patient with neurofibromatosis type 1. We report this rare case along with a review of the literature.
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U2 - 10.1186/1752-1947-5-521
DO - 10.1186/1752-1947-5-521
M3 - Article
VL - 5
JO - Journal of Medical Case Reports
JF - Journal of Medical Case Reports
SN - 1752-1947
M1 - 521
ER -