Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers

A case report

Kazuya Kato, Atsushi Nagase, Kazuhiko Onodera, Minoru Matsuda, Yoshiaki Iwasaki, Yurina Kato, Kimitaka Kato, Takako Kawakami, Masahiko Taniguchi, Hiroyuki Furukawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction. Gastric tumors in patients affected by neurofibromatosis type 1 are usually carcinoids or stromal tumors, and rarely adenocarcinomas. Case presentation. We report a case of an adenocarcinoma of the stomach in a 53-year-old Japanese man with neurofibromatosis type 1. An abdominal computed tomography scan and ultrasonography showed tumors in his liver. Gastric fibroscopy revealed a Borrmann type III tumor on his cardia that had spread to his esophagus and was highly suspicious for malignancy. Multiple biopsies showed an adenocarcinoma of the stomach, which was evaluated as gastric cancer, stage IV. Chemotherapy with TS-1 was performed. Our patient died four weeks after initial admission. Histological examination of a liver needle biopsy showed metastatic adenocarcinoma in his liver. Conclusion: To the best of our knowledge, high serum levels of -fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 72-4, resulting from gastric adenocarcinoma, have not been reported previously in a patient with neurofibromatosis type 1. We report this rare case along with a review of the literature.

Original languageEnglish
Article number521
JournalJournal of Medical Case Reports
Volume5
DOIs
Publication statusPublished - 2011

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Neurofibromatosis 1
Tumor Biomarkers
Stomach
Adenocarcinoma
Serum
Neoplasms
Liver
Fetal Proteins
Cardia
Carcinoembryonic Antigen
Carcinoid Tumor
Needle Biopsy
Esophagus
Stomach Neoplasms
Ultrasonography
Tomography
Biopsy
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)

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Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers : A case report. / Kato, Kazuya; Nagase, Atsushi; Onodera, Kazuhiko; Matsuda, Minoru; Iwasaki, Yoshiaki; Kato, Yurina; Kato, Kimitaka; Kawakami, Takako; Taniguchi, Masahiko; Furukawa, Hiroyuki.

In: Journal of Medical Case Reports, Vol. 5, 521, 2011.

Research output: Contribution to journalArticle

Kato, Kazuya ; Nagase, Atsushi ; Onodera, Kazuhiko ; Matsuda, Minoru ; Iwasaki, Yoshiaki ; Kato, Yurina ; Kato, Kimitaka ; Kawakami, Takako ; Taniguchi, Masahiko ; Furukawa, Hiroyuki. / Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers : A case report. In: Journal of Medical Case Reports. 2011 ; Vol. 5.
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AU - Matsuda, Minoru

AU - Iwasaki, Yoshiaki

AU - Kato, Yurina

AU - Kato, Kimitaka

AU - Kawakami, Takako

AU - Taniguchi, Masahiko

AU - Furukawa, Hiroyuki

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