TY - JOUR
T1 - Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion
AU - Kondo, Yoichi
AU - Ogawa, Norio
AU - Asanuma, Masato
AU - Matsuura, Koji
AU - Nishibayashi, Sakiko
AU - Iwata, Emi
N1 - Funding Information:
This study was supportedin part by grants-in-aifdo r ScientificR esearcho n Priority Area and ScientificR e-search from the JapaneseM inistry of Education, Science, Sports and Culture, and the grants for The Research Committee of CNS DegenerativeD iseases and ResearchP rojectson Aging and Health from the JapaneseM inistry of Health and Welfare.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/3
Y1 - 1996/3
N2 - Changes in muscarinic acetylcholine receptor (mACh-R) binding and muscarinic cholinergic ml receptor (ml-R) mRNA levels were determined in a rat model of cerebral hypoperfusion in which hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. After 6 weeks of hypoperfusion, mACh-R binding activity was significantly reduced in the frontal cortex (79.0%, P < 0.01), striatum (74.2%, P < 0.01) and hippocampus (78.6%, P < 0.01), and the ml-R mRNA levels in the frontal cortex (86.6%, P < 0.05) and striatum (89.4%, P < 0.05) compared with sham-operated control. Repeated administration of bifemelane hydrochloride (15 mg/kg/day, p.o., once a day from the day of operation for 6 weeks) prevented the hypoperfusion-induced loss of mACh-R binding and ml-R mRNA levels above described. Since the central cholinergic systems play an important role in learning and memory, these findings suggest that bifemelane hydrochloride is useful to treat and/or prevent vascular dementia which is closely related to cerebral hypoperfusion.
AB - Changes in muscarinic acetylcholine receptor (mACh-R) binding and muscarinic cholinergic ml receptor (ml-R) mRNA levels were determined in a rat model of cerebral hypoperfusion in which hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. After 6 weeks of hypoperfusion, mACh-R binding activity was significantly reduced in the frontal cortex (79.0%, P < 0.01), striatum (74.2%, P < 0.01) and hippocampus (78.6%, P < 0.01), and the ml-R mRNA levels in the frontal cortex (86.6%, P < 0.05) and striatum (89.4%, P < 0.05) compared with sham-operated control. Repeated administration of bifemelane hydrochloride (15 mg/kg/day, p.o., once a day from the day of operation for 6 weeks) prevented the hypoperfusion-induced loss of mACh-R binding and ml-R mRNA levels above described. Since the central cholinergic systems play an important role in learning and memory, these findings suggest that bifemelane hydrochloride is useful to treat and/or prevent vascular dementia which is closely related to cerebral hypoperfusion.
KW - 2VO
KW - Bifemelane hydrochloride
KW - Cholinergic system
KW - Chronic cerebral hypoperfusion
KW - Permanent occlusion
KW - Vascular dementia
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U2 - 10.1016/0168-0102(95)01017-3
DO - 10.1016/0168-0102(95)01017-3
M3 - Article
C2 - 8861111
AN - SCOPUS:0029913848
VL - 24
SP - 409
EP - 414
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 4
ER -