Abstract
Changes in muscarinic acetylcholine receptor (mACh-R) binding and muscarinic cholinergic ml receptor (ml-R) mRNA levels were determined in a rat model of cerebral hypoperfusion in which hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. After 6 weeks of hypoperfusion, mACh-R binding activity was significantly reduced in the frontal cortex (79.0%, P <0.01), striatum (74.2%, P <0.01) and hippocampus (78.6%, P <0.01), and the ml-R mRNA levels in the frontal cortex (86.6%, P <0.05) and striatum (89.4%, P <0.05) compared with sham-operated control. Repeated administration of bifemelane hydrochloride (15 mg/kg/day, p.o., once a day from the day of operation for 6 weeks) prevented the hypoperfusion-induced loss of mACh-R binding and ml-R mRNA levels above described. Since the central cholinergic systems play an important role in learning and memory, these findings suggest that bifemelane hydrochloride is useful to treat and/or prevent vascular dementia which is closely related to cerebral hypoperfusion.
| Original language | English |
|---|---|
| Pages (from-to) | 409-414 |
| Number of pages | 6 |
| Journal | Neuroscience Research |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Mar 1996 |
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Keywords
- 2VO
- Bifemelane hydrochloride
- Cholinergic system
- Chronic cerebral hypoperfusion
- Permanent occlusion
- Vascular dementia
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion. / Kondo, Yoichi; Ogawa, Norio; Asanuma, Masato; Matsuura, Koji; Nishibayashi, Sakiko; Iwata, Emi.
In: Neuroscience Research, Vol. 24, No. 4, 03.1996, p. 409-414.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion
AU - Kondo, Yoichi
AU - Ogawa, Norio
AU - Asanuma, Masato
AU - Matsuura, Koji
AU - Nishibayashi, Sakiko
AU - Iwata, Emi
PY - 1996/3
Y1 - 1996/3
N2 - Changes in muscarinic acetylcholine receptor (mACh-R) binding and muscarinic cholinergic ml receptor (ml-R) mRNA levels were determined in a rat model of cerebral hypoperfusion in which hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. After 6 weeks of hypoperfusion, mACh-R binding activity was significantly reduced in the frontal cortex (79.0%, P <0.01), striatum (74.2%, P <0.01) and hippocampus (78.6%, P <0.01), and the ml-R mRNA levels in the frontal cortex (86.6%, P <0.05) and striatum (89.4%, P <0.05) compared with sham-operated control. Repeated administration of bifemelane hydrochloride (15 mg/kg/day, p.o., once a day from the day of operation for 6 weeks) prevented the hypoperfusion-induced loss of mACh-R binding and ml-R mRNA levels above described. Since the central cholinergic systems play an important role in learning and memory, these findings suggest that bifemelane hydrochloride is useful to treat and/or prevent vascular dementia which is closely related to cerebral hypoperfusion.
AB - Changes in muscarinic acetylcholine receptor (mACh-R) binding and muscarinic cholinergic ml receptor (ml-R) mRNA levels were determined in a rat model of cerebral hypoperfusion in which hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. After 6 weeks of hypoperfusion, mACh-R binding activity was significantly reduced in the frontal cortex (79.0%, P <0.01), striatum (74.2%, P <0.01) and hippocampus (78.6%, P <0.01), and the ml-R mRNA levels in the frontal cortex (86.6%, P <0.05) and striatum (89.4%, P <0.05) compared with sham-operated control. Repeated administration of bifemelane hydrochloride (15 mg/kg/day, p.o., once a day from the day of operation for 6 weeks) prevented the hypoperfusion-induced loss of mACh-R binding and ml-R mRNA levels above described. Since the central cholinergic systems play an important role in learning and memory, these findings suggest that bifemelane hydrochloride is useful to treat and/or prevent vascular dementia which is closely related to cerebral hypoperfusion.
KW - 2VO
KW - Bifemelane hydrochloride
KW - Cholinergic system
KW - Chronic cerebral hypoperfusion
KW - Permanent occlusion
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=0029913848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029913848&partnerID=8YFLogxK
U2 - 10.1016/0168-0102(95)01017-3
DO - 10.1016/0168-0102(95)01017-3
M3 - Article
C2 - 8861111
AN - SCOPUS:0029913848
VL - 24
SP - 409
EP - 414
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 4
ER -