Prevention of Visual Field Defect Progression With Angiotensin-Converting Enzyme Inhibitor in Eyes With Normal-tension Glaucoma

Kazuyuki Hirooka, Tetsuya Baba, Takashi Fujimura, Fumio Shiraga

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: To report the effect of angiotensin-converting enzyme (ACE) inhibitor on visual field changes in normal-tension glaucoma (NTG). Design: Retrospective observational case series. Methods: We retrospectively reviewed a total of 38 patients with NTG. Control subjects had no previous history of hypertension. NTG hypertension patients were divided into two groups, those receiving ACE inhibitor and those receiving other antihypertensive drug treatments. HfaFiles 5, an analytical program for the Humphrey Field Analyzer, was used to calculate the slope for the mean deviation (MD) change per year. Results: In the ACE inhibitor-treated group, the mean MD change per year was 0.48 ± 0.19 dB, in control subjects was -0.38 ± 0.23 dB, and in the other antihypertensive drug-treated group was -0.50 ± 0.39 dB. Conclusions: Although the present study is retrospective and the sample size is small, ACE inhibitor might have a favorable effect on the visual field in patients with NTG in this small study.

Original languageEnglish
Pages (from-to)523-525
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume142
Issue number3
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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