Prevention of type I diabetes by low-dose gamma irradiation in NOD mice

M. Takahashi, S. Kojima, Kiyonori Yamaoka, E. Niki

Research output: Contribution to journalArticle

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Abstract

Pretreatment with nonlethal, low-dose irradiation has been shown to have a protective effect against oxidative injury in animal tissues. Since oxidative injury of tissues is known to be a major cause of many human diseases, we examined the effect of low-dose irradiation on the progression of type I diabetes in mice. Nonobese diabetic (NOD) mice were treated with y irradiation and the progression of the disease was monitored. An elevated level of glucose in urine was first detected at 15 weeks of age in the control NOD mice, whereas the detection was delayed as long as 7 weeks when the mice received a single dose of 0.5 Gy total-body irradiation between 12 and 14 weeks of age. The greatest effect was observed in the mice irradiated at 13 weeks of age. The increase in blood glucose and decrease in blood insulin were effectively suppressed by irradiation at 13 weeks of age. Both suppression of cell death by apoptosis and an increase in superoxide dismutase (SOD) activity were observed in the pancreas 1 week after irradiation. The results indicate that treatment with 0.5 Gy y rays suppresses progression of type I diabetes in NOD mice. This is the first report on the preventive effect of low-dose irradiation on disease progression. (C) 2000 by Radiation Research Society.

Original languageEnglish
Pages (from-to)680-685
Number of pages6
JournalRadiation Research
Volume154
Issue number6
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Inbred NOD Mouse
insulin-dependent diabetes mellitus
Type 1 Diabetes Mellitus
gamma radiation
mice
irradiation
dosage
Disease Progression
progressions
Whole-Body Irradiation
Wounds and Injuries
Superoxide Dismutase
Blood Glucose
Pancreas
disease course
glucose
Cell Death
blood
Urine
Insulin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Prevention of type I diabetes by low-dose gamma irradiation in NOD mice. / Takahashi, M.; Kojima, S.; Yamaoka, Kiyonori; Niki, E.

In: Radiation Research, Vol. 154, No. 6, 2000, p. 680-685.

Research output: Contribution to journalArticle

Takahashi, M, Kojima, S, Yamaoka, K & Niki, E 2000, 'Prevention of type I diabetes by low-dose gamma irradiation in NOD mice', Radiation Research, vol. 154, no. 6, pp. 680-685.
Takahashi, M. ; Kojima, S. ; Yamaoka, Kiyonori ; Niki, E. / Prevention of type I diabetes by low-dose gamma irradiation in NOD mice. In: Radiation Research. 2000 ; Vol. 154, No. 6. pp. 680-685.
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