Prevention of human cancer by modulation of chronic inflammatory processes

Hiroshi Ohshima, Hiroshi Tazawa, Bakary S. Sylla, Tomohiro Sawa

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Chronic inflammation induced by biological, chemical and physical factors has been associated with increased risk of human cancer at various sites. Inflammation facilitates the initiation of normal cells and their growth and progression to malignancy through production of pro-inflammatory cytokines and diverse reactive oxygen and nitrogen species. These also activate signaling molecules involved in inflammation and carcinogenesis such as nuclear transcription factor (NF-κB), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Several chemopreventive agents act through inhibition of signaling pathways (e.g. NF-κB), inhibition of oxidant-generating enzymes (e.g. iNOS) and mediators of inflammation (e.g. COX-2), scavenging reactive oxygen and nitrogen species, and modulation of xenobiotic-metabolizing enzymes (especially phase II enzyme induction). Some anti-inflammatory drugs have been tested in clinical trials to prevent human cancer at several sites. Better understanding of the molecular mechanisms by which chronic inflammation increases cancer risk will lead to further development of new strategies for cancer prevention at many sites.

Original languageEnglish
Pages (from-to)110-122
Number of pages13
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume591
Issue number1-2
DOIs
Publication statusPublished - Dec 11 2005
Externally publishedYes

Keywords

  • COX-2
  • Cancer
  • Inflammation
  • NF-κB
  • Reactive nitrogen species
  • Reactive oxygen species
  • iNOS

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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