Prevention of catheter-related infections using a closed hub system in patients with pulmonary arterial hypertension

Satoshi Akagi, Hiromi Matsubara, Aiko Ogawa, Yusuke Kawai, Kenichi Hisamatsu, Katsumasa Miyaji, Mitsuru Munemasa, Yoshihisa Fujimoto, Kengo Fukushima Kusano, Tohru Ohe

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27 Citations (Scopus)

Abstract

Background: Most of the patients with pulmonary arterial hypertension (PAH) receiving intravenous epoprostenol have experienced catheter-related infections during long-term treatment. Catheter hub was reported to be the most important source of catheter-related infections. To prevent the catheter-related infections, we have introduced a closed hub system and compared the incidence of catheter-related infections with that in patients using a non-closed hub system. Methods and Results: We evaluated the results obtained on 24 occasions in 20 patients with PAH between June 1999 and December 2005. On 11 occasions, a non-closed hub system was used and on 13 cases a closed hub system. We classified the catheter-related infection into a catheter-related bloodstream infection (CRBSI) group or a tunnel infection group based on the pathway of bacteria. The CRBSI rate was 0.89 per 1,000 catheter days in the non-closed hub system group vs 0.10 per 1,000 catheter days in the closed hub system group. Kaplan - Meier analysis showed that the risk of CRBSI significantly decreased in the closed hub system group. None of the patients died as a direct consequence of catheter-related infection during the study period. Conclusions: We successfully prevented CRBSI by using a closed hub system.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalCirculation Journal
Volume71
Issue number4
DOIs
Publication statusPublished - Apr 8 2007
Externally publishedYes

Keywords

  • Catheter-related bloodstream infection
  • Catheter-related infection
  • Closed hub system
  • Epoprostenol
  • Pulmonary arterial hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Akagi, S., Matsubara, H., Ogawa, A., Kawai, Y., Hisamatsu, K., Miyaji, K., Munemasa, M., Fujimoto, Y., Kusano, K. F., & Ohe, T. (2007). Prevention of catheter-related infections using a closed hub system in patients with pulmonary arterial hypertension. Circulation Journal, 71(4), 559-564. https://doi.org/10.1253/circj.71.559