Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate

Tetsushi Taguchi, Masahiro Okada, Yasumichi Kogai, Miwa Masuda, Yumi Shimomura, Motoki Inoue, Temmei Ito, Takashi Hamahata, Keiji Funatogawa, Teruo Kirikae, Tsutomu Furuzono

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new material was prepared to reduce catheter infection composed of a flocked silicone sheet (AmTiO2NP-F) with TiO2 nanoparticle-immobilized poly(ethylene terephthalate) fibers modified with surface amino groups. This system was used in conjunction with a tissue adhesive composed of disuccinimidyl tartrate and human serum albumin. At a fixed disuccinimidyl tartrate content of 0.2 mmol in human serum albumin solution, AmTiO2NP-F bonded well with collagen-based casing (a model material for skin), with bond strength increasing to a maximum of 38 w/v% human serum albumin. The adhesive bonded AmTiO2NP-F to subcutaneous tissue in mice, and infiltration of the tissue into the AmTiO2NP-F further increased the bond strength for long-term insertions. The material was degraded within 7 days of implantation, and tissue reaction was mild, while infection was completely prevented. These results indicate that the combined use of AmTiO2NP-F and disuccinimidyl tartrate-A for implanted catheters can significantly alleviate the associated risk of infection.

Original languageEnglish
Pages (from-to)284-297
Number of pages14
JournalJournal of Bioactive and Compatible Polymers
Volume29
Issue number3
DOIs
Publication statusPublished - May 2014

    Fingerprint

Keywords

  • Adhesive
  • Catheter
  • Human serum albumin
  • Infection
  • Organic acid

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Taguchi, T., Okada, M., Kogai, Y., Masuda, M., Shimomura, Y., Inoue, M., Ito, T., Hamahata, T., Funatogawa, K., Kirikae, T., & Furuzono, T. (2014). Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate. Journal of Bioactive and Compatible Polymers, 29(3), 284-297. https://doi.org/10.1177/0883911514528409