Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line

Koji Abe, Kyuya Kogure

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin, chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism. Diphenylhydantoin and chlorpromazine were found to have positive effects only when they were administered before the addition of calcium. This was in contrast to flunarizine, which showed a protective effect only in combination with calcium. However, leupeptin did not show any positive effect, indicating that calcium-activated neutral protease may be only slightly involved in this type of calcium-induced cell damage.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalNeuroscience Letters
Volume80
Issue number3
DOIs
Publication statusPublished - Oct 5 1987
Externally publishedYes

Keywords

  • Calcium paradox
  • Chlorpromazine
  • Diphenylhydantoin
  • Flunarizine
  • Leupeptin
  • Neuroblastoma cell line

ASJC Scopus subject areas

  • Neuroscience(all)

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