Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats

N. Hotta, N. Koh, F. Sakakibara, J. Nakamura, Y. Hamada, T. Wakao, T. Hara, K. Moil, K. Naruse, K. Nakashima, H. Fukasawa, H. Kakuta

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11 Citations (Scopus)

Abstract

The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P < 0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P < 0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.

Original languageEnglish
Pages (from-to)339-349
Number of pages11
JournalProstaglandins
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 1995
Externally publishedYes

Keywords

  • Prostacyclin
  • motor nerve conduction velocity
  • sciatic nerve blood-flow
  • streptozotocin-induced diabetic rats
  • thromboxane B

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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    Hotta, N., Koh, N., Sakakibara, F., Nakamura, J., Hamada, Y., Wakao, T., Hara, T., Moil, K., Naruse, K., Nakashima, K., Fukasawa, H., & Kakuta, H. (1995). Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. Prostaglandins, 49(6), 339-349. https://doi.org/10.1016/0090-6980(95)00066-J