Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats

N. Hotta; N. Koh; F. Sakakibara; J. Nakamura; Y. Hamada; T. Wakao; T. Hara; K. Moil; K. Naruse; K. Nakashima; H. Fukasawa; H. Kakuta

doi:10.1016/0090-6980(95)00066-J

Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats

N. Hotta, N. Koh, F. Sakakibara, J. Nakamura, Y. Hamada, T. Wakao, T. Hara, K. Moil, K. Naruse, K. Nakashima, H. Fukasawa, H. Kakuta

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P < 0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B₂ in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P < 0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.

Original language	English
Pages (from-to)	339-349
Number of pages	11
Journal	Prostaglandins
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/0090-6980(95)00066-J
Publication status	Published - Jun 1995
Externally published	Yes

Keywords

Prostacyclin
motor nerve conduction velocity
sciatic nerve blood-flow
streptozotocin-induced diabetic rats
thromboxane B

ASJC Scopus subject areas

Biochemistry
Endocrinology

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10.1016/0090-6980(95)00066-J

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Hotta, N., Koh, N., Sakakibara, F., Nakamura, J., Hamada, Y., Wakao, T., Hara, T., Moil, K., Naruse, K., Nakashima, K., Fukasawa, H., & Kakuta, H. (1995). Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. Prostaglandins, 49(6), 339-349. https://doi.org/10.1016/0090-6980(95)00066-J

Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. / Hotta, N.; Koh, N.; Sakakibara, F.; Nakamura, J.; Hamada, Y.; Wakao, T.; Hara, T.; Moil, K.; Naruse, K.; Nakashima, K.; Fukasawa, H.; Kakuta, H.

In: Prostaglandins, Vol. 49, No. 6, 06.1995, p. 339-349.

Research output: Contribution to journal › Article › peer-review

Hotta, N, Koh, N, Sakakibara, F, Nakamura, J, Hamada, Y, Wakao, T, Hara, T, Moil, K, Naruse, K, Nakashima, K, Fukasawa, H & Kakuta, H 1995, 'Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats', Prostaglandins, vol. 49, no. 6, pp. 339-349. https://doi.org/10.1016/0090-6980(95)00066-J

Hotta, N. ; Koh, N. ; Sakakibara, F. ; Nakamura, J. ; Hamada, Y. ; Wakao, T. ; Hara, T. ; Moil, K. ; Naruse, K. ; Nakashima, K. ; Fukasawa, H. ; Kakuta, H. / Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. In: Prostaglandins. 1995 ; Vol. 49, No. 6. pp. 339-349.

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abstract = "The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P < 0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P < 0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.",

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