TY - JOUR
T1 - Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats
AU - Hotta, N.
AU - Koh, N.
AU - Sakakibara, F.
AU - Nakamura, J.
AU - Hamada, Y.
AU - Wakao, T.
AU - Hara, T.
AU - Moil, K.
AU - Naruse, K.
AU - Nakashima, K.
AU - Fukasawa, H.
AU - Kakuta, H.
N1 - Funding Information:
This research was supported in part by a Diabetes Research grant from the Ministry of Health and Welfare of Japan.
PY - 1995/6
Y1 - 1995/6
N2 - The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P < 0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P < 0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.
AB - The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P < 0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P < 0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.
KW - Prostacyclin
KW - motor nerve conduction velocity
KW - sciatic nerve blood-flow
KW - streptozotocin-induced diabetic rats
KW - thromboxane B
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U2 - 10.1016/0090-6980(95)00066-J
DO - 10.1016/0090-6980(95)00066-J
M3 - Article
C2 - 7480803
AN - SCOPUS:0029164826
VL - 49
SP - 339
EP - 349
JO - Prostaglandins
JF - Prostaglandins
SN - 0090-6980
IS - 6
ER -
