Abstract
The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P <0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P <0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.
| Original language | English |
|---|---|
| Pages (from-to) | 339-349 |
| Number of pages | 11 |
| Journal | Prostaglandins |
| Volume | 49 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1995 |
| Externally published | Yes |
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Keywords
- motor nerve conduction velocity
- Prostacyclin
- sciatic nerve blood-flow
- streptozotocin-induced diabetic rats
- thromboxane B
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. / Hotta, N.; Koh, N.; Sakakibara, F.; Nakamura, J.; Hamada, Y.; Wakao, T.; Hara, T.; Moil, K.; Naruse, Keiji; Nakashima, K.; Fukasawa, H.; Kakuta, H.
In: Prostaglandins, Vol. 49, No. 6, 1995, p. 339-349.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats
AU - Hotta, N.
AU - Koh, N.
AU - Sakakibara, F.
AU - Nakamura, J.
AU - Hamada, Y.
AU - Wakao, T.
AU - Hara, T.
AU - Moil, K.
AU - Naruse, Keiji
AU - Nakashima, K.
AU - Fukasawa, H.
AU - Kakuta, H.
PY - 1995
Y1 - 1995
N2 - The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P <0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P <0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.
AB - The effects of the prostacyclin analog beraprost sodium on motor nerve function and nerve blood-flow were examined in streptozotocin-induced diabetic rats. Oral administration of beraprost sodium 0.1 mg/kg/day for 8 wks significantly (P <0.001) improved caudal motor nerve conduction velocity and sciatic nerve blood-flow, both of which are impaired in diabetic rats. Beraprost sodium did not affect glucose, sorbitol, or fructose levels in the sciatic nerve. However, a decreased content of cyclic AMP in the sciatic nerve and higher level of thromboxane B2 in the thoracic aorta of diabetic rats, as compared with those in normal rats, were reversed by the treatment with beraprost sodium (P <0.01). Results suggest that beraprost sodium may have value in treating diabetic neuropathy, mainly by improving endoneurial blood-flow.
KW - motor nerve conduction velocity
KW - Prostacyclin
KW - sciatic nerve blood-flow
KW - streptozotocin-induced diabetic rats
KW - thromboxane B
UR - http://www.scopus.com/inward/record.url?scp=0029164826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029164826&partnerID=8YFLogxK
U2 - 10.1016/0090-6980(95)00066-J
DO - 10.1016/0090-6980(95)00066-J
M3 - Article
C2 - 7480803
AN - SCOPUS:0029164826
VL - 49
SP - 339
EP - 349
JO - Prostaglandins and Other Lipid Mediators
JF - Prostaglandins and Other Lipid Mediators
SN - 1098-8823
IS - 6
ER -