Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan

Hideki Ueno, Hirotoshi Kobayashi, Tsuyoshi Konishi, Fumio Ishida, Tatsuro Yamaguchi, Takao Hinoi, Yukihide Kanemitsu, Yasuhiro Inoue, Naohiro Tomita, Nagahide Matsubara, Koji Komori, Heita Ozawa, Takeshi Nagasaka, Hirotoshi Hasegawa, Motoi Koyama, Yoshito Akagi, Toshimasa Yatsuoka, Kensuke Kumamoto, Kiyotaka Kurachi, Kohji Tanakaya & 4 others Kazuhiko Yoshimatsu, Toshiaki Watanabe, Kenichi Sugihara, Hideyuki Ishida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Abstract: Background: Laparoscopic surgery is becoming the preferred technique for most colorectal interventions. This study aimed to clarify the time trend of surgical treatment for familial adenomatous polyposis (FAP) and its relevance to clinical outcomes in Japan over a 13-year period. Abstract: Methods: This was a multicenter retrospective cohort study comprising 23 specialist institutions for colorectal disease and a cohort of 282 FAP patients who underwent total colectomy or proctocolectomy during 2000–2012. Patient clinical backgrounds and surgical outcomes were compared between the first and second halves of the study period. Abstract: Results: The proportion of surgical types adopted over the entire study period was 46, 21, 30, and 3 % for ileoanal anastomosis (IAA), ileoanal canal anastomosis, ileorectal anastomosis, and permanent ileostomy, respectively. FAP patients undergoing laparoscopic surgery have increased since 2008 and reached 74 % in the past 3 years. In particular, the number of patients undergoing laparoscopic proctocolectomy with IAA increased approximately four-fold from the first to the second half of the study period. A laparoscopic approach was increasingly used in patients with coexisting colorectal malignancies. Despite this trend, surgical results of the laparoscopic approach between the two study periods showed similar morbidity, pouch operation and stoma closure completion rates. No postoperative mortality was observed in this series, and laparoscopic surgery was comparable to open surgery in terms of stoma closure rate, incidence of intra-abdominal/abdominal desmoid tumors, and postoperative survival rate in both study periods. Abstract: Conclusion: Laparoscopic approach is increasingly being adopted for prophylactic FAP surgery in Japan and may provide clinically acceptable practical outcomes.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalInternational Journal of Clinical Oncology
DOIs
Publication statusAccepted/In press - Jan 28 2016

Fingerprint

Adenomatous Polyposis Coli
Japan
Laparoscopy
Aggressive Fibromatosis
Therapeutics
Ileostomy
Colectomy
Neoplasms
Cohort Studies
Survival Rate
Retrospective Studies
Morbidity
Mortality
Incidence

Keywords

  • Desmoid tumor
  • Familial adenomatous polyposis (FAP)
  • Laparoscopic surgery
  • Total colectomy
  • Total proctocolectomy

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Hematology

Cite this

Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan. / Ueno, Hideki; Kobayashi, Hirotoshi; Konishi, Tsuyoshi; Ishida, Fumio; Yamaguchi, Tatsuro; Hinoi, Takao; Kanemitsu, Yukihide; Inoue, Yasuhiro; Tomita, Naohiro; Matsubara, Nagahide; Komori, Koji; Ozawa, Heita; Nagasaka, Takeshi; Hasegawa, Hirotoshi; Koyama, Motoi; Akagi, Yoshito; Yatsuoka, Toshimasa; Kumamoto, Kensuke; Kurachi, Kiyotaka; Tanakaya, Kohji; Yoshimatsu, Kazuhiko; Watanabe, Toshiaki; Sugihara, Kenichi; Ishida, Hideyuki.

In: International Journal of Clinical Oncology, 28.01.2016, p. 1-10.

Research output: Contribution to journalArticle

Ueno, H, Kobayashi, H, Konishi, T, Ishida, F, Yamaguchi, T, Hinoi, T, Kanemitsu, Y, Inoue, Y, Tomita, N, Matsubara, N, Komori, K, Ozawa, H, Nagasaka, T, Hasegawa, H, Koyama, M, Akagi, Y, Yatsuoka, T, Kumamoto, K, Kurachi, K, Tanakaya, K, Yoshimatsu, K, Watanabe, T, Sugihara, K & Ishida, H 2016, 'Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan', International Journal of Clinical Oncology, pp. 1-10. https://doi.org/10.1007/s10147-016-0953-5
Ueno, Hideki ; Kobayashi, Hirotoshi ; Konishi, Tsuyoshi ; Ishida, Fumio ; Yamaguchi, Tatsuro ; Hinoi, Takao ; Kanemitsu, Yukihide ; Inoue, Yasuhiro ; Tomita, Naohiro ; Matsubara, Nagahide ; Komori, Koji ; Ozawa, Heita ; Nagasaka, Takeshi ; Hasegawa, Hirotoshi ; Koyama, Motoi ; Akagi, Yoshito ; Yatsuoka, Toshimasa ; Kumamoto, Kensuke ; Kurachi, Kiyotaka ; Tanakaya, Kohji ; Yoshimatsu, Kazuhiko ; Watanabe, Toshiaki ; Sugihara, Kenichi ; Ishida, Hideyuki. / Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan. In: International Journal of Clinical Oncology. 2016 ; pp. 1-10.
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AU - Ueno, Hideki

AU - Kobayashi, Hirotoshi

AU - Konishi, Tsuyoshi

AU - Ishida, Fumio

AU - Yamaguchi, Tatsuro

AU - Hinoi, Takao

AU - Kanemitsu, Yukihide

AU - Inoue, Yasuhiro

AU - Tomita, Naohiro

AU - Matsubara, Nagahide

AU - Komori, Koji

AU - Ozawa, Heita

AU - Nagasaka, Takeshi

AU - Hasegawa, Hirotoshi

AU - Koyama, Motoi

AU - Akagi, Yoshito

AU - Yatsuoka, Toshimasa

AU - Kumamoto, Kensuke

AU - Kurachi, Kiyotaka

AU - Tanakaya, Kohji

AU - Yoshimatsu, Kazuhiko

AU - Watanabe, Toshiaki

AU - Sugihara, Kenichi

AU - Ishida, Hideyuki

PY - 2016/1/28

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N2 - Abstract: Background: Laparoscopic surgery is becoming the preferred technique for most colorectal interventions. This study aimed to clarify the time trend of surgical treatment for familial adenomatous polyposis (FAP) and its relevance to clinical outcomes in Japan over a 13-year period. Abstract: Methods: This was a multicenter retrospective cohort study comprising 23 specialist institutions for colorectal disease and a cohort of 282 FAP patients who underwent total colectomy or proctocolectomy during 2000–2012. Patient clinical backgrounds and surgical outcomes were compared between the first and second halves of the study period. Abstract: Results: The proportion of surgical types adopted over the entire study period was 46, 21, 30, and 3 % for ileoanal anastomosis (IAA), ileoanal canal anastomosis, ileorectal anastomosis, and permanent ileostomy, respectively. FAP patients undergoing laparoscopic surgery have increased since 2008 and reached 74 % in the past 3 years. In particular, the number of patients undergoing laparoscopic proctocolectomy with IAA increased approximately four-fold from the first to the second half of the study period. A laparoscopic approach was increasingly used in patients with coexisting colorectal malignancies. Despite this trend, surgical results of the laparoscopic approach between the two study periods showed similar morbidity, pouch operation and stoma closure completion rates. No postoperative mortality was observed in this series, and laparoscopic surgery was comparable to open surgery in terms of stoma closure rate, incidence of intra-abdominal/abdominal desmoid tumors, and postoperative survival rate in both study periods. Abstract: Conclusion: Laparoscopic approach is increasingly being adopted for prophylactic FAP surgery in Japan and may provide clinically acceptable practical outcomes.

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