Prevalence of homozygous deletions of the parkin gene in a cohort of patients with sporadic and familial Parkinson's disease

Hiroshi Ujike, Mitsutoshi Yamamoto, Akihiro Kanzaki, Kazuya Okumura, Manabu Takaki, Shigetoshi Kuroda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mutation of the parkin gene is a cause of familial Parkinson's disease of the autosomal recessive form; however, its significance in all Parkinson's disease cases is unclear. Deletions in the parkin gene were found in only 2.2% of 184 Japanese patients with Parkinson's disease. However, deletions were present in 25.0% and 40.0% of the patients with juvenile-onset (< 40 y) and with familiality, respectively. On the other hand, deletions were not found in any adult-onset cases (> 40 y). Half of the patients with parkin gene-related Parkinson's disease lacked both heredity and consanguinity.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalMovement Disorders
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • AR-JP
  • Cohort study
  • Homozygous deletion
  • Parkin gene
  • Prevalence

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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