TY - JOUR
T1 - Prevalence of Antibody against Non‐A, non‐B Hepatitis Virus in Japanese Patients with Hepatocellular Carcinoma
AU - Ohkoshi, Showgo
AU - Kojima, Hideo
AU - Tawaraya, Hironobu
AU - Miyajima, Tohru
AU - Kamimura, Tomoteru
AU - Asakura, Hitoshi
AU - Satoh, Akira
AU - Hirose, Shinichi
AU - Hijikata, Makoto
AU - Kato, Nobuyuki
AU - Shimotohno, Kunitada
PY - 1990/6
Y1 - 1990/6
N2 - Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan.
AB - Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan.
KW - Antibody
KW - Hepatitis C virus
KW - Hepatocellular carcinoma
KW - Non‐A, non‐B hepatitis virus
UR - http://www.scopus.com/inward/record.url?scp=0025309010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025309010&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.1990.tb02605.x
DO - 10.1111/j.1349-7006.1990.tb02605.x
M3 - Article
C2 - 2169469
AN - SCOPUS:0025309010
VL - 81
SP - 550
EP - 553
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 6-7
ER -
