Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder

Tomoyuki Honda, Kozue Sofuku, Hidenori Matsunaga, Masaya Tachibana, Ikuko Mohri, Masako Taniike, Keizo Tomonaga

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus-specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline-data for future studies regarding bornavirus epidemiology in children.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume62
Issue number7
DOIs
Publication statusPublished - Jul 2018
Externally publishedYes

Keywords

  • antibody
  • autism
  • bornavirus
  • epidemiology

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

Fingerprint

Dive into the research topics of 'Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder'. Together they form a unique fingerprint.

Cite this