Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010

Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Sohji Nishina, Masaaki Korenaga, Keisuke Hino, Shin Ichi Fujioka, Toshiya Osawa, Tatsuya Itoshima, Miwa Kawanaka, Gotaro Yamada, Kazuya Kariyama, Hiroki Takayama, Junichi Kubota, Yoichi Morimoto, Takaaki Mizushima, Haruhiko Yamashita, Hiroaki Tanioka, Yuji Negoro, Junichi ToshimoriHaruhiko Kobashi, Atsushi Hirano, Yasuo Itano, Akinobu Takaki, Kazuhide Yamamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalActa medica Okayama
Volume68
Issue number4
Publication statusPublished - 2014

Keywords

  • Acute hepatitis
  • Hepatitis B virus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wada, N., Yasunaka, T., Ikeda, F., Nishina, S., Korenaga, M., Hino, K., Fujioka, S. I., Osawa, T., Itoshima, T., Kawanaka, M., Yamada, G., Kariyama, K., Takayama, H., Kubota, J., Morimoto, Y., Mizushima, T., Yamashita, H., Tanioka, H., Negoro, Y., ... Yamamoto, K. (2014). Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010. Acta medica Okayama, 68(4), 243-247.