Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

Taro Misaki, Shuhei Naka, Rina Hatakeyama, Akiko Fukunaga, Ryota Nomura, Taisuke Isozaki, Kazuhiko Nakano

Research output: Contribution to journalArticle

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Abstract

Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of several systemic diseases. In this study, we analysed S. mutans strains isolated from the oral cavity of immunoglobulin (Ig)A nephropathy (IgAN) patients to determine potential relationships between cnm and caries status as well as IgAN conditions. Saliva specimens were collected from 109 IgAN patients and the cnm status of isolated S. mutans strains was determined using PCR. In addition, the dental caries status (decayed, missing or filled teeth [DMFT] index) in patients who agreed to dental consultation (n = 49) was evaluated. The DMFT index and urinary protein levels in the cnm-positive group were significantly higher than those in the cnm-negative group (p < 0.05). Moreover, the urinary protein levels in the high DMFT (≥15) group were significantly higher than those in the low DMFT (<15) group (p < 0.05). Our results show that isolation of cnm-positive S. mutans strains from the oral cavity may be associated with urinary protein levels in IgAN patients, especially those with a high dental caries status.

Original languageEnglish
Article number36455
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Nov 4 2016
Externally publishedYes

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DMF Index
Streptococcus mutans
Dental Caries
Immunoglobulin A
Genes
Mouth
IGA Glomerulonephritis
Proteins
Saliva
Tooth
Carrier Proteins
Collagen
Referral and Consultation
Polymerase Chain Reaction

ASJC Scopus subject areas

  • General

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Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions. / Misaki, Taro; Naka, Shuhei; Hatakeyama, Rina; Fukunaga, Akiko; Nomura, Ryota; Isozaki, Taisuke; Nakano, Kazuhiko.

In: Scientific Reports, Vol. 6, 36455, 04.11.2016.

Research output: Contribution to journalArticle

Misaki, Taro ; Naka, Shuhei ; Hatakeyama, Rina ; Fukunaga, Akiko ; Nomura, Ryota ; Isozaki, Taisuke ; Nakano, Kazuhiko. / Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions. In: Scientific Reports. 2016 ; Vol. 6.
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