Presence of human β-defensin-2 in oral squamous cell carcinoma

Nobuyoshi Mizukawa, Koichi Sawaki, Eiki Yamachika, Joji Fukunaga, Takaaki Ueno, Shin Takagi, Toshio Sugahara

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26 Citations (Scopus)


The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.

Original languageEnglish
Pages (from-to)2005-2007
Number of pages3
JournalAnticancer research
Issue number3 B
Publication statusPublished - 2000


  • Defensin
  • HBD-2
  • Oral carcinoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Mizukawa, N., Sawaki, K., Yamachika, E., Fukunaga, J., Ueno, T., Takagi, S., & Sugahara, T. (2000). Presence of human β-defensin-2 in oral squamous cell carcinoma. Anticancer research, 20(3 B), 2005-2007.