Abstract
The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.
| Original language | English |
|---|---|
| Pages (from-to) | 2005-2007 |
| Number of pages | 3 |
| Journal | Anticancer Research |
| Volume | 20 |
| Issue number | 3 B |
| Publication status | Published - 2000 |
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Keywords
- Defensin
- HBD-2
- Oral carcinoma
- Squamous cell carcinoma
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Presence of human β-defensin-2 in oral squamous cell carcinoma. / Mizukawa, Nobuyoshi; Sawaki, Koichi; Yamachika, Eiki; Fukunaga, Joji; Ueno, Takaaki; Takagi, Shin; Sugahara, Toshio.
In: Anticancer Research, Vol. 20, No. 3 B, 2000, p. 2005-2007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of human β-defensin-2 in oral squamous cell carcinoma
AU - Mizukawa, Nobuyoshi
AU - Sawaki, Koichi
AU - Yamachika, Eiki
AU - Fukunaga, Joji
AU - Ueno, Takaaki
AU - Takagi, Shin
AU - Sugahara, Toshio
PY - 2000
Y1 - 2000
N2 - The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.
AB - The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.
KW - Defensin
KW - HBD-2
KW - Oral carcinoma
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0033898814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033898814&partnerID=8YFLogxK
M3 - Article
C2 - 10928142
AN - SCOPUS:0033898814
VL - 20
SP - 2005
EP - 2007
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 3 B
ER -