Presence of human β-defensin-2 in oral squamous cell carcinoma

Nobuyoshi Mizukawa; Koichi Sawaki; Eiki Yamachika; Joji Fukunaga; Takaaki Ueno; Shin Takagi; Toshio Sugahara

Presence of human β-defensin-2 in oral squamous cell carcinoma

Nobuyoshi Mizukawa, Koichi Sawaki, Eiki Yamachika, Joji Fukunaga, Takaaki Ueno, Shin Takagi, Toshio Sugahara

University Hospital

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.

Original language	English
Pages (from-to)	2005-2007
Number of pages	3
Journal	Anticancer research
Volume	20
Issue number	3 B
Publication status	Published - 2000

Keywords

Defensin
HBD-2
Oral carcinoma
Squamous cell carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Presence of human β-defensin-2 in oral squamous cell carcinoma",

abstract = "The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.",

keywords = "Defensin, HBD-2, Oral carcinoma, Squamous cell carcinoma",

author = "Nobuyoshi Mizukawa and Koichi Sawaki and Eiki Yamachika and Joji Fukunaga and Takaaki Ueno and Shin Takagi and Toshio Sugahara",

year = "2000",

language = "English",

volume = "20",

pages = "2005--2007",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Presence of human β-defensin-2 in oral squamous cell carcinoma

AU - Mizukawa, Nobuyoshi

AU - Sawaki, Koichi

AU - Yamachika, Eiki

AU - Fukunaga, Joji

AU - Ueno, Takaaki

AU - Takagi, Shin

AU - Sugahara, Toshio

PY - 2000

Y1 - 2000

N2 - The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.

AB - The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.

KW - Defensin

KW - HBD-2

KW - Oral carcinoma

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0033898814&partnerID=8YFLogxK

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M3 - Article

C2 - 10928142

AN - SCOPUS:0033898814

VL - 20

SP - 2005

EP - 2007

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 3 B

ER -

Presence of human β-defensin-2 in oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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