Abstract
The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.
| Original language | English |
|---|---|
| Pages (from-to) | 2005-2007 |
| Number of pages | 3 |
| Journal | Anticancer research |
| Volume | 20 |
| Issue number | 3 B |
| Publication status | Published - 2000 |
Keywords
- Defensin
- HBD-2
- Oral carcinoma
- Squamous cell carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Mizukawa, N., Sawaki, K., Yamachika, E., Fukunaga, J., Ueno, T., Takagi, S., & Sugahara, T. (2000). Presence of human β-defensin-2 in oral squamous cell carcinoma. Anticancer research, 20(3 B), 2005-2007.