Presence of human β-defensin-2 in oral squamous cell carcinoma

Nobuyoshi Mizukawa, Koichi Sawaki, Eiki Yamachika, Joji Fukunaga, Takaaki Ueno, Shin Takagi, Toshio Sugahara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The purpose of this study was to demonstrate immunohistochemically the localization and distibution of human β-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.

Original languageEnglish
Pages (from-to)2005-2007
Number of pages3
JournalAnticancer Research
Volume20
Issue number3 B
Publication statusPublished - 2000

Fingerprint

Defensins
Squamous Cell Carcinoma
Streptavidin
Biotin
Paraffin
Peroxidase
Neoplasms
Carcinoma
Peptides
Antibodies

Keywords

  • Defensin
  • HBD-2
  • Oral carcinoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mizukawa, N., Sawaki, K., Yamachika, E., Fukunaga, J., Ueno, T., Takagi, S., & Sugahara, T. (2000). Presence of human β-defensin-2 in oral squamous cell carcinoma. Anticancer Research, 20(3 B), 2005-2007.

Presence of human β-defensin-2 in oral squamous cell carcinoma. / Mizukawa, Nobuyoshi; Sawaki, Koichi; Yamachika, Eiki; Fukunaga, Joji; Ueno, Takaaki; Takagi, Shin; Sugahara, Toshio.

In: Anticancer Research, Vol. 20, No. 3 B, 2000, p. 2005-2007.

Research output: Contribution to journalArticle

Mizukawa, N, Sawaki, K, Yamachika, E, Fukunaga, J, Ueno, T, Takagi, S & Sugahara, T 2000, 'Presence of human β-defensin-2 in oral squamous cell carcinoma', Anticancer Research, vol. 20, no. 3 B, pp. 2005-2007.
Mizukawa N, Sawaki K, Yamachika E, Fukunaga J, Ueno T, Takagi S et al. Presence of human β-defensin-2 in oral squamous cell carcinoma. Anticancer Research. 2000;20(3 B):2005-2007.
Mizukawa, Nobuyoshi ; Sawaki, Koichi ; Yamachika, Eiki ; Fukunaga, Joji ; Ueno, Takaaki ; Takagi, Shin ; Sugahara, Toshio. / Presence of human β-defensin-2 in oral squamous cell carcinoma. In: Anticancer Research. 2000 ; Vol. 20, No. 3 B. pp. 2005-2007.
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