Prepubertal Changes in Immunoreactive Inhibin Concentration in Blood Serum and Testicular Tissue in Holstein Bull Calves

Sigenori Matsuzaki, Yoshihisa Uenoyama, Kiyoshi Okuda, Gen Watanabe, Nobuo Kitamura, Kazuyoshi Taya, Maria Bella C Cruzana, Junzo Yamada

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Age-related changes in immunoreactive inhibin (ir-inhibin) levels and the relationship among ir-inhibin, gonadotropins and testosterone were examined in 53 Holstein bull calves from neonates to 8.6 months old. Serum levels of ir-inhibin, luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone, as well as ir-inhibin levels in testicular extracts, and testicular sizes were measured. All hormones were measured by specific radioimmunoassays. The concentrations of ir-inhibin in serum and testicular tissue were high in neonatal calves and tended to decrease with age. In contrast, serum concentrations of gonadotropins did not show any age-related changes within the experimental period. Serum testosterone levels and testicular sizes (length, width and weight) were positively correlated with age. Furthermore, a positive immunostaining to antiserum for the inhibin α-subunit was immunocytochemically observed only in Sertoli cells of the seminiferous tubules from neonates to calves less than 6 months old. These results indicate that the immature bovine testis produces and secretes high levels of ir-inhibin and that the Sertoli cells are a major source of ir-inhibin in prepubertal bull calves.

Original languageEnglish
Pages (from-to)1303-1307
Number of pages5
JournalJournal of Veterinary Medical Science
Volume63
Issue number12
DOIs
Publication statusPublished - Dec 2001

Fingerprint

inhibin
Inhibins
blood serum
bulls
Holstein
calves
Serum
testosterone
Testosterone
Sertoli Cells
Sertoli cells
gonadotropins
Gonadotropins
neonates
Seminiferous Tubules
seminiferous tubules
tissues
Inhibin
Calves
follicle-stimulating hormone

Keywords

  • Bull
  • Gonadotropin
  • Inhibin
  • Sertoli cell
  • Testosterone

ASJC Scopus subject areas

  • Marketing
  • veterinary(all)

Cite this

Prepubertal Changes in Immunoreactive Inhibin Concentration in Blood Serum and Testicular Tissue in Holstein Bull Calves. / Matsuzaki, Sigenori; Uenoyama, Yoshihisa; Okuda, Kiyoshi; Watanabe, Gen; Kitamura, Nobuo; Taya, Kazuyoshi; Cruzana, Maria Bella C; Yamada, Junzo.

In: Journal of Veterinary Medical Science, Vol. 63, No. 12, 12.2001, p. 1303-1307.

Research output: Contribution to journalArticle

Matsuzaki, S, Uenoyama, Y, Okuda, K, Watanabe, G, Kitamura, N, Taya, K, Cruzana, MBC & Yamada, J 2001, 'Prepubertal Changes in Immunoreactive Inhibin Concentration in Blood Serum and Testicular Tissue in Holstein Bull Calves', Journal of Veterinary Medical Science, vol. 63, no. 12, pp. 1303-1307. https://doi.org/10.1292/jvms.63.1303
Matsuzaki, Sigenori ; Uenoyama, Yoshihisa ; Okuda, Kiyoshi ; Watanabe, Gen ; Kitamura, Nobuo ; Taya, Kazuyoshi ; Cruzana, Maria Bella C ; Yamada, Junzo. / Prepubertal Changes in Immunoreactive Inhibin Concentration in Blood Serum and Testicular Tissue in Holstein Bull Calves. In: Journal of Veterinary Medical Science. 2001 ; Vol. 63, No. 12. pp. 1303-1307.
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