Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis

M. Aoki, Y. Kikuchi, Koji Abe, H. Kurosawa, H. Ogawa, A. Mizusawa, W. Hida

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To evaluate whether the endogenous opioid system is activated in the higher brain centre while a chronic resistance to airflow, we examined changes of mRNAs for preproenkephalin (PPE)-A, which is a precursor of enkephalin, and for 70 kD heat shock protein (HSP70) in the cerebral cortex of rat brain during chronic tracheal stenosis. Northern blot revealed that PPE-A mRNA was induced at 3 days of airway stenosis. In situ hybridization revealed that PPE-A mRNA was gradually induced in frontal cortex. The significant induction of PPE-A mRNA was observed at 3 and 7 days. However, no significant induction of HSP70 gene was observed. These results suggest that the endogenous opioid system may be at work as an important compensatory mechanism to reduce the respiratory sensation during chronic respiratory stress.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalNeurological Research
Volume16
Issue number3
Publication statusPublished - 1994
Externally publishedYes

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Tracheal Stenosis
Cerebral Cortex
Gene Expression
Messenger RNA
HSP70 Heat-Shock Proteins
Opioid Analgesics
Enkephalins
Brain
Frontal Lobe
Northern Blotting
In Situ Hybridization
Pathologic Constriction
preproenkephalin
Genes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Aoki, M., Kikuchi, Y., Abe, K., Kurosawa, H., Ogawa, H., Mizusawa, A., & Hida, W. (1994). Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis. Neurological Research, 16(3), 213-216.

Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis. / Aoki, M.; Kikuchi, Y.; Abe, Koji; Kurosawa, H.; Ogawa, H.; Mizusawa, A.; Hida, W.

In: Neurological Research, Vol. 16, No. 3, 1994, p. 213-216.

Research output: Contribution to journalArticle

Aoki, M, Kikuchi, Y, Abe, K, Kurosawa, H, Ogawa, H, Mizusawa, A & Hida, W 1994, 'Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis', Neurological Research, vol. 16, no. 3, pp. 213-216.
Aoki M, Kikuchi Y, Abe K, Kurosawa H, Ogawa H, Mizusawa A et al. Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis. Neurological Research. 1994;16(3):213-216.
Aoki, M. ; Kikuchi, Y. ; Abe, Koji ; Kurosawa, H. ; Ogawa, H. ; Mizusawa, A. ; Hida, W. / Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis. In: Neurological Research. 1994 ; Vol. 16, No. 3. pp. 213-216.
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