Preparation of tiny biodegradable capsules using electrocapillary emulsification

Masahiko Abe, Ai Nakayama, Tamotsu Kondo, Hiroshi Morishita, Koji Tsuchiya, Shigenori Utsumi, Takahiro Ohkubo, Hideki Sakai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.

Original languageEnglish
Pages (from-to)777-786
Number of pages10
JournalJournal of Microencapsulation
Volume24
Issue number8
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

Fingerprint

Emulsification
capsules
Surface-Active Agents
juices
Capsules
Oils
oils
surfactants
preparation
Surface active agents
direct current
proteins
Proteins
Gastric Juice
agitation
Lactoferrin
Polysorbates
Nonionic surfactants
Cyclohexane
Emulsions

Keywords

  • Biodegradable capsule
  • Electrocapillary emulsification
  • Lactoferrin
  • Polycyanoacrylate
  • Polymerization

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Chemical Engineering(all)
  • Pharmacology

Cite this

Abe, M., Nakayama, A., Kondo, T., Morishita, H., Tsuchiya, K., Utsumi, S., ... Sakai, H. (2007). Preparation of tiny biodegradable capsules using electrocapillary emulsification. Journal of Microencapsulation, 24(8), 777-786. https://doi.org/10.1080/02652040701644752

Preparation of tiny biodegradable capsules using electrocapillary emulsification. / Abe, Masahiko; Nakayama, Ai; Kondo, Tamotsu; Morishita, Hiroshi; Tsuchiya, Koji; Utsumi, Shigenori; Ohkubo, Takahiro; Sakai, Hideki.

In: Journal of Microencapsulation, Vol. 24, No. 8, 12.2007, p. 777-786.

Research output: Contribution to journalArticle

Abe, M, Nakayama, A, Kondo, T, Morishita, H, Tsuchiya, K, Utsumi, S, Ohkubo, T & Sakai, H 2007, 'Preparation of tiny biodegradable capsules using electrocapillary emulsification', Journal of Microencapsulation, vol. 24, no. 8, pp. 777-786. https://doi.org/10.1080/02652040701644752
Abe, Masahiko ; Nakayama, Ai ; Kondo, Tamotsu ; Morishita, Hiroshi ; Tsuchiya, Koji ; Utsumi, Shigenori ; Ohkubo, Takahiro ; Sakai, Hideki. / Preparation of tiny biodegradable capsules using electrocapillary emulsification. In: Journal of Microencapsulation. 2007 ; Vol. 24, No. 8. pp. 777-786.
@article{608657827d074fc1bcd5ec6f52a03a62,
title = "Preparation of tiny biodegradable capsules using electrocapillary emulsification",
abstract = "Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5{\%} of the protein used in encapsulation without losing its activity.",
keywords = "Biodegradable capsule, Electrocapillary emulsification, Lactoferrin, Polycyanoacrylate, Polymerization",
author = "Masahiko Abe and Ai Nakayama and Tamotsu Kondo and Hiroshi Morishita and Koji Tsuchiya and Shigenori Utsumi and Takahiro Ohkubo and Hideki Sakai",
year = "2007",
month = "12",
doi = "10.1080/02652040701644752",
language = "English",
volume = "24",
pages = "777--786",
journal = "Journal of Microencapsulation",
issn = "0265-2048",
publisher = "Informa Healthcare",
number = "8",

}

TY - JOUR

T1 - Preparation of tiny biodegradable capsules using electrocapillary emulsification

AU - Abe, Masahiko

AU - Nakayama, Ai

AU - Kondo, Tamotsu

AU - Morishita, Hiroshi

AU - Tsuchiya, Koji

AU - Utsumi, Shigenori

AU - Ohkubo, Takahiro

AU - Sakai, Hideki

PY - 2007/12

Y1 - 2007/12

N2 - Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.

AB - Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.

KW - Biodegradable capsule

KW - Electrocapillary emulsification

KW - Lactoferrin

KW - Polycyanoacrylate

KW - Polymerization

UR - http://www.scopus.com/inward/record.url?scp=35248897091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35248897091&partnerID=8YFLogxK

U2 - 10.1080/02652040701644752

DO - 10.1080/02652040701644752

M3 - Article

VL - 24

SP - 777

EP - 786

JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

SN - 0265-2048

IS - 8

ER -