Abstract
Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.
| Original language | English |
|---|---|
| Pages (from-to) | 777-786 |
| Number of pages | 10 |
| Journal | Journal of Microencapsulation |
| Volume | 24 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Dec 2007 |
| Externally published | Yes |
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Keywords
- Biodegradable capsule
- Electrocapillary emulsification
- Lactoferrin
- Polycyanoacrylate
- Polymerization
ASJC Scopus subject areas
- Chemistry (miscellaneous)
- Pharmaceutical Science
- Chemical Engineering(all)
- Pharmacology
Cite this
Preparation of tiny biodegradable capsules using electrocapillary emulsification. / Abe, Masahiko; Nakayama, Ai; Kondo, Tamotsu; Morishita, Hiroshi; Tsuchiya, Koji; Utsumi, Shigenori; Ohkubo, Takahiro; Sakai, Hideki.
In: Journal of Microencapsulation, Vol. 24, No. 8, 12.2007, p. 777-786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preparation of tiny biodegradable capsules using electrocapillary emulsification
AU - Abe, Masahiko
AU - Nakayama, Ai
AU - Kondo, Tamotsu
AU - Morishita, Hiroshi
AU - Tsuchiya, Koji
AU - Utsumi, Shigenori
AU - Ohkubo, Takahiro
AU - Sakai, Hideki
PY - 2007/12
Y1 - 2007/12
N2 - Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.
AB - Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.
KW - Biodegradable capsule
KW - Electrocapillary emulsification
KW - Lactoferrin
KW - Polycyanoacrylate
KW - Polymerization
UR - http://www.scopus.com/inward/record.url?scp=35248897091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35248897091&partnerID=8YFLogxK
U2 - 10.1080/02652040701644752
DO - 10.1080/02652040701644752
M3 - Article
VL - 24
SP - 777
EP - 786
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
SN - 0265-2048
IS - 8
ER -