Preparation of porous organically-modified silicate hybrids cell culture matrix

K. Tsuru, S. Hayakawa, Y. Shirosaki, T. Okayama, K. Kataoka, N. H. Huh, A. Osaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

Original languageEnglish
Pages (from-to)1177-1180
Number of pages4
JournalKey Engineering Materials
Volume330-332 II
DOIs
Publication statusPublished - Jan 1 2007

Keywords

  • Bioreactor
  • Cell culture
  • HepG2
  • Inorganic-organic hybrids
  • Scaffolds

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Preparation of porous organically-modified silicate hybrids cell culture matrix'. Together they form a unique fingerprint.

  • Cite this

    Tsuru, K., Hayakawa, S., Shirosaki, Y., Okayama, T., Kataoka, K., Huh, N. H., & Osaka, A. (2007). Preparation of porous organically-modified silicate hybrids cell culture matrix. Key Engineering Materials, 330-332 II, 1177-1180. https://doi.org/10.4028/0-87849-422-7.1177