Preparation of porous organically-modified silicate hybrids cell culture matrix

K. Tsuru, Satoshi Hayakawa, Y. Shirosaki, T. Okayama, K. Kataoka, N. H. Huh, A. Osaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

Original languageEnglish
Pages (from-to)1177-1180
Number of pages4
JournalKey Engineering Materials
Volume330-332 II
Publication statusPublished - 2007

Fingerprint

Silicates
Polydimethylsiloxane
Cell culture
Sugar (sucrose)
Polymers
Scaffolds
Sol-gels
Sucrose
Porosity
Cells
Chemical analysis
baysilon
tetraethoxysilane

Keywords

  • Bioreactor
  • Cell culture
  • HepG2
  • Inorganic-organic hybrids
  • Scaffolds

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Tsuru, K., Hayakawa, S., Shirosaki, Y., Okayama, T., Kataoka, K., Huh, N. H., & Osaka, A. (2007). Preparation of porous organically-modified silicate hybrids cell culture matrix. Key Engineering Materials, 330-332 II, 1177-1180.

Preparation of porous organically-modified silicate hybrids cell culture matrix. / Tsuru, K.; Hayakawa, Satoshi; Shirosaki, Y.; Okayama, T.; Kataoka, K.; Huh, N. H.; Osaka, A.

In: Key Engineering Materials, Vol. 330-332 II, 2007, p. 1177-1180.

Research output: Contribution to journalArticle

Tsuru, K, Hayakawa, S, Shirosaki, Y, Okayama, T, Kataoka, K, Huh, NH & Osaka, A 2007, 'Preparation of porous organically-modified silicate hybrids cell culture matrix', Key Engineering Materials, vol. 330-332 II, pp. 1177-1180.
Tsuru K, Hayakawa S, Shirosaki Y, Okayama T, Kataoka K, Huh NH et al. Preparation of porous organically-modified silicate hybrids cell culture matrix. Key Engineering Materials. 2007;330-332 II:1177-1180.
Tsuru, K. ; Hayakawa, Satoshi ; Shirosaki, Y. ; Okayama, T. ; Kataoka, K. ; Huh, N. H. ; Osaka, A. / Preparation of porous organically-modified silicate hybrids cell culture matrix. In: Key Engineering Materials. 2007 ; Vol. 330-332 II. pp. 1177-1180.
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