Preparation of nanocrystalline zinc-substituted hydroxyapatite films and their biological properties

Tania Guadalupe Peñaflor Galindo, Takuya Kataoka, Shuji Fujii, Mitushiro Okuda, Motohiro Tagaya

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Nanocrystalline zinc (Zn)-substituted hydroxyapatite (HAp) films were prepared and electrically-plated on a titanium-coated silicone to investigate the biological properties. The hydroxyapatite nanocrystals with the different initial molar (Zn + Ca)/P ratios (1.67 and 2.00) and Zn ion concentrations were synthesized and subsequently coated by an electrophoretic deposition method to successfully form homogenous thin films. The nanocrystalline films provided bioactive properties based on the fibroblast ingrowth as well as the reduction in the number of viable Escherichia coli. Therefore, the optimized cytocompatible and antibacterial properties of the films by the effective Zn ion substituted in the HAp will be useful as a silicone surface modification technique.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalColloids and Interface Science Communications
Publication statusPublished - Jan 1 2016
Externally publishedYes


  • Bioceramics
  • Biomaterials
  • Electrophoretic deposition
  • Hydroxyapatite
  • Nano-bio interfaces

ASJC Scopus subject areas

  • Biotechnology
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry
  • Materials Chemistry


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