Preparation of nanocrystalline zinc-substituted hydroxyapatite films and their biological properties

Tania Guadalupe Peñaflor Galindo; Takuya Kataoka; Shuji Fujii; Mitushiro Okuda; Motohiro Tagaya

doi:10.1016/j.colcom.2016.03.005

Preparation of nanocrystalline zinc-substituted hydroxyapatite films and their biological properties

Tania Guadalupe Peñaflor Galindo, Takuya Kataoka, Shuji Fujii, Mitushiro Okuda, Motohiro Tagaya

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Nanocrystalline zinc (Zn)-substituted hydroxyapatite (HAp) films were prepared and electrically-plated on a titanium-coated silicone to investigate the biological properties. The hydroxyapatite nanocrystals with the different initial molar (Zn + Ca)/P ratios (1.67 and 2.00) and Zn ion concentrations were synthesized and subsequently coated by an electrophoretic deposition method to successfully form homogenous thin films. The nanocrystalline films provided bioactive properties based on the fibroblast ingrowth as well as the reduction in the number of viable Escherichia coli. Therefore, the optimized cytocompatible and antibacterial properties of the films by the effective Zn ion substituted in the HAp will be useful as a silicone surface modification technique.

Original language	English
Pages (from-to)	15-19
Number of pages	5
Journal	Colloids and Interface Science Communications
Volume	10-11
DOIs	https://doi.org/10.1016/j.colcom.2016.03.005
Publication status	Published - Jan 1 2016
Externally published	Yes

Keywords

Bioceramics
Biomaterials
Electrophoretic deposition
Hydroxyapatite
Nano-bio interfaces

ASJC Scopus subject areas

Biotechnology
Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Colloid and Surface Chemistry
Materials Chemistry

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10.1016/j.colcom.2016.03.005

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abstract = "Nanocrystalline zinc (Zn)-substituted hydroxyapatite (HAp) films were prepared and electrically-plated on a titanium-coated silicone to investigate the biological properties. The hydroxyapatite nanocrystals with the different initial molar (Zn + Ca)/P ratios (1.67 and 2.00) and Zn ion concentrations were synthesized and subsequently coated by an electrophoretic deposition method to successfully form homogenous thin films. The nanocrystalline films provided bioactive properties based on the fibroblast ingrowth as well as the reduction in the number of viable Escherichia coli. Therefore, the optimized cytocompatible and antibacterial properties of the films by the effective Zn ion substituted in the HAp will be useful as a silicone surface modification technique.",

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author = "{Pe{\~n}aflor Galindo}, {Tania Guadalupe} and Takuya Kataoka and Shuji Fujii and Mitushiro Okuda and Motohiro Tagaya",

note = "Funding Information: This study was supported by a grant from the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 26709052 (Grant-in-Aid for Young Scientists (A)) and also partially supported by Izumi Science and Technology Foundation No. H26-J-028 . The authors thank Prof. Dr. Takaomi Kobayashi for many helpful discussions. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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doi = "10.1016/j.colcom.2016.03.005",

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T1 - Preparation of nanocrystalline zinc-substituted hydroxyapatite films and their biological properties

AU - Peñaflor Galindo, Tania Guadalupe

AU - Kataoka, Takuya

AU - Fujii, Shuji

AU - Okuda, Mitushiro

AU - Tagaya, Motohiro

N1 - Funding Information: This study was supported by a grant from the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 26709052 (Grant-in-Aid for Young Scientists (A)) and also partially supported by Izumi Science and Technology Foundation No. H26-J-028 . The authors thank Prof. Dr. Takaomi Kobayashi for many helpful discussions. Publisher Copyright: © 2016 Elsevier B.V.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Nanocrystalline zinc (Zn)-substituted hydroxyapatite (HAp) films were prepared and electrically-plated on a titanium-coated silicone to investigate the biological properties. The hydroxyapatite nanocrystals with the different initial molar (Zn + Ca)/P ratios (1.67 and 2.00) and Zn ion concentrations were synthesized and subsequently coated by an electrophoretic deposition method to successfully form homogenous thin films. The nanocrystalline films provided bioactive properties based on the fibroblast ingrowth as well as the reduction in the number of viable Escherichia coli. Therefore, the optimized cytocompatible and antibacterial properties of the films by the effective Zn ion substituted in the HAp will be useful as a silicone surface modification technique.

AB - Nanocrystalline zinc (Zn)-substituted hydroxyapatite (HAp) films were prepared and electrically-plated on a titanium-coated silicone to investigate the biological properties. The hydroxyapatite nanocrystals with the different initial molar (Zn + Ca)/P ratios (1.67 and 2.00) and Zn ion concentrations were synthesized and subsequently coated by an electrophoretic deposition method to successfully form homogenous thin films. The nanocrystalline films provided bioactive properties based on the fibroblast ingrowth as well as the reduction in the number of viable Escherichia coli. Therefore, the optimized cytocompatible and antibacterial properties of the films by the effective Zn ion substituted in the HAp will be useful as a silicone surface modification technique.

KW - Bioceramics

KW - Biomaterials

KW - Electrophoretic deposition

KW - Hydroxyapatite

KW - Nano-bio interfaces

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JO - Colloids and Interface Science Communications

JF - Colloids and Interface Science Communications

ER -

Preparation of nanocrystalline zinc-substituted hydroxyapatite films and their biological properties

Abstract

Keywords

ASJC Scopus subject areas

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