Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups

Makoto Muranaka; Tsutomu Ono

doi:10.1002/marc.200800620

Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups

Makoto Muranaka, Tsutomu Ono

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Monodisperse poly(D,L-lactide) (PDLLA) microspheres have been prepared by dispersion polymerization of D,L-lactide with a synthetic polymeric stabilizer. The polymerization is carried out in xylene/heptane (1:2, v/v) at 368 K for 3 h with poly[(dodecyl methacrylate)-co-(2- hydroxyethyl methacrylate)] (P(DMA-co-HEMA)). P(DMA-co-HEMA) has hydroxy groups as an initiation group for pseudoanionic dispersion polymerization. The particle diameter and the coefficient of variation concerning the diameter distribution of the obtained PDLLA microspheres are 3.9 μm and 4.3%, respectively. In addition, from the results of dynamic light scattering measurements, it is found that P(DMA-co-HEMA) and the PDLLA-grafted copolymer form a micellar structure in solution.

Original language	English
Pages (from-to)	152-156
Number of pages	5
Journal	Macromolecular Rapid Communications
Volume	30
Issue number	3
DOIs	https://doi.org/10.1002/marc.200800620
Publication status	Published - Feb 2 2009

Keywords

Dispersion polymerization
Graft copolymers
Micelles
Monodisperse polylactide microspheres
Polymeric stabilizers
Unimers

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1002/marc.200800620

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title = "Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups",

abstract = "Monodisperse poly(D,L-lactide) (PDLLA) microspheres have been prepared by dispersion polymerization of D,L-lactide with a synthetic polymeric stabilizer. The polymerization is carried out in xylene/heptane (1:2, v/v) at 368 K for 3 h with poly[(dodecyl methacrylate)-co-(2- hydroxyethyl methacrylate)] (P(DMA-co-HEMA)). P(DMA-co-HEMA) has hydroxy groups as an initiation group for pseudoanionic dispersion polymerization. The particle diameter and the coefficient of variation concerning the diameter distribution of the obtained PDLLA microspheres are 3.9 μm and 4.3%, respectively. In addition, from the results of dynamic light scattering measurements, it is found that P(DMA-co-HEMA) and the PDLLA-grafted copolymer form a micellar structure in solution.",

keywords = "Dispersion polymerization, Graft copolymers, Micelles, Monodisperse polylactide microspheres, Polymeric stabilizers, Unimers",

author = "Makoto Muranaka and Tsutomu Ono",

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T1 - Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups

AU - Muranaka, Makoto

AU - Ono, Tsutomu

PY - 2009/2/2

Y1 - 2009/2/2

N2 - Monodisperse poly(D,L-lactide) (PDLLA) microspheres have been prepared by dispersion polymerization of D,L-lactide with a synthetic polymeric stabilizer. The polymerization is carried out in xylene/heptane (1:2, v/v) at 368 K for 3 h with poly[(dodecyl methacrylate)-co-(2- hydroxyethyl methacrylate)] (P(DMA-co-HEMA)). P(DMA-co-HEMA) has hydroxy groups as an initiation group for pseudoanionic dispersion polymerization. The particle diameter and the coefficient of variation concerning the diameter distribution of the obtained PDLLA microspheres are 3.9 μm and 4.3%, respectively. In addition, from the results of dynamic light scattering measurements, it is found that P(DMA-co-HEMA) and the PDLLA-grafted copolymer form a micellar structure in solution.

AB - Monodisperse poly(D,L-lactide) (PDLLA) microspheres have been prepared by dispersion polymerization of D,L-lactide with a synthetic polymeric stabilizer. The polymerization is carried out in xylene/heptane (1:2, v/v) at 368 K for 3 h with poly[(dodecyl methacrylate)-co-(2- hydroxyethyl methacrylate)] (P(DMA-co-HEMA)). P(DMA-co-HEMA) has hydroxy groups as an initiation group for pseudoanionic dispersion polymerization. The particle diameter and the coefficient of variation concerning the diameter distribution of the obtained PDLLA microspheres are 3.9 μm and 4.3%, respectively. In addition, from the results of dynamic light scattering measurements, it is found that P(DMA-co-HEMA) and the PDLLA-grafted copolymer form a micellar structure in solution.

KW - Dispersion polymerization

KW - Graft copolymers

KW - Micelles

KW - Monodisperse polylactide microspheres

KW - Polymeric stabilizers

KW - Unimers

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DO - 10.1002/marc.200800620

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JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 3

ER -

Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups

Abstract

Keywords

ASJC Scopus subject areas

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