Preparation of injectable hydroxyapatite/collagen nanocomposite artificial bone

Akinori Kochi, Masanori Kikuchi, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


Injectable hydroxyapatite/collagen nanocomposite (HAp/Col) artificial bone was prepared utilizing gelation of sodium alginate (Na-Alg). Mass ratio of the HAp/Col powder, with or without Ca adsorption treatment and Na-Alg (80-120, 300-400, 500-600 cP in viscosity at 10 g/dm3) was fixed at 90/10. Injectable HAp/Col was prepared by mixing the HAp/Col powder with Na-Alg solution at several powder (HAp/Col)/liquid (Na-Alg solution) ratios (P/L ratio, g/cm3). The result of consistency measurement suggested that the operability of injectable HAp/Col paste could be controlled by both the P/L ratio and the viscosity of Na-Alg solution. According to the consistency measurement and practical feelings during mixing, P/L=1/1.67 (80-120 cP) and 1/1.89 (300-400, 500-600 cP) were considered to be the highest P/L ratio allowed to mix the HAp/Col paste with a spatula. At the P/L=1/2.33 (80-120 cP), the paste prepared with the non-treated HAp/Col powder, placed in an incubator (37 °C,relative humidity 100%) for 24h, demonstrated gellike property, while the paste prepared with Ca-treated HAp/Col powder did putty-like property. The difference in their property might be caused by the initial bonding behavior between Alg and Ca2+ after mixing. The setting time measurement with Gillmore needle was impossible because they were toosoft for this method. Even though, their operability and coalescence/settingproperty could be used as the injectable bone filler.

Original languageEnglish
Title of host publicationBioceramics 23
PublisherTrans Tech Publications Ltd
Number of pages4
ISBN (Print)9783037852552
Publication statusPublished - 2012
Event23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011 - Istanbul, Turkey
Duration: Nov 6 2011Nov 9 2011

Publication series

NameKey Engineering Materials
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795


Other23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011


  • Bone filler
  • HAp/col
  • Injectable
  • Sodium alginate

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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