Preparation of hydroxyapatite nanoparticles applying the micro chemical process

Eiji Fujii, Koji Kawabata, Yoshiaki Nakazaki, Yuji Tanizawa, Akihiro Matsumoto, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A micro-chemical process was applied to prepare nanometer-size hydroxy apatite (HA) particles with various shapes and sizes so as to provide high surface activities, where solutions of reagent-grade calcium nitrate tetrahydrate and diammonium hydrogen phosphate were introduced in a micro reactor. The particles were characterized by X-ray diffractometry, transmission electron microscopy, or inductively coupled plasma photometry. Particle size and shape were dependent on not only pH and concentration of the mixing solutions but also the flow rate. Dilute solutions containing 3 mM Ca(II) and 5 mM P(V) yielded spherical HA particles, whose average particle size increased from about 3 nm to 40 nm as the flow rate increased from 0.3 to 3 ml·min -1, where pH and the temperature of the reaction system were respectively maintained at 10 and at 40°C. Concentrated solutions with 50 mM Ca(II) and 30 mM P(V) yielded rectangular plate-like HA particles, 300 nm long and 50 nm wide, when pH was kept at 8, while agglomerations of smaller HA particles of about 20-50 nm were obtained when pH was kept at 10.

Original languageEnglish
Title of host publicationAdvances in Bioceramics and Biotechnologies - A Collection of Papers Presented at the 8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM-8
Pages185-190
Number of pages6
Publication statusPublished - Sep 1 2010
Event8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM-8 - Vancouver, BC, Canada
Duration: May 31 2009Jun 5 2009

Publication series

NameCeramic Transactions
Volume218
ISSN (Print)1042-1122

Other

Other8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM-8
CountryCanada
CityVancouver, BC
Period5/31/096/5/09

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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  • Cite this

    Fujii, E., Kawabata, K., Nakazaki, Y., Tanizawa, Y., Matsumoto, A., Shirosaki, Y., Hayakawa, S., & Osaka, A. (2010). Preparation of hydroxyapatite nanoparticles applying the micro chemical process. In Advances in Bioceramics and Biotechnologies - A Collection of Papers Presented at the 8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM-8 (pp. 185-190). (Ceramic Transactions; Vol. 218).