Abstract
A micro-chemical process was applied to prepare nanometer-size hydroxy apatite (HA) particles with various shapes and sizes so as to provide high surface activities, where solutions of reagent-grade calcium nitrate tetrahydrate and diammonium hydrogen phosphate were introduced in a micro reactor. The particles were characterized by X-ray diffractometry, transmission electron microscopy, or inductively coupled plasma photometry. Particle size and shape were dependent on not only pH and concentration of the mixing solutions but also the flow rate. Dilute solutions containing 3 mM Ca(II) and 5 mM P(V) yielded spherical HA particles, whose average particle size increased from about 3 nm to 40 nm as the flow rate increased from 0.3 to 3 ml·min -1, where pH and the temperature of the reaction system were respectively maintained at 10 and at 40°C. Concentrated solutions with 50 mM Ca(II) and 30 mM P(V) yielded rectangular plate-like HA particles, 300 nm long and 50 nm wide, when pH was kept at 8, while agglomerations of smaller HA particles of about 20-50 nm were obtained when pH was kept at 10.
| Original language | English |
|---|---|
| Title of host publication | Ceramic Transactions |
| Pages | 185-190 |
| Number of pages | 6 |
| Volume | 218 |
| Publication status | Published - 2010 |
| Event | 8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM-8 - Vancouver, BC, Canada Duration: May 31 2009 → Jun 5 2009 |
Publication series
| Name | Ceramic Transactions |
|---|---|
| Volume | 218 |
| ISSN (Print) | 10421122 |
Other
| Other | 8th Pacific Rim Conference on Ceramic and Glass Technology, PACRIM-8 |
|---|---|
| Country | Canada |
| City | Vancouver, BC |
| Period | 5/31/09 → 6/5/09 |
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ASJC Scopus subject areas
- Ceramics and Composites
- Materials Chemistry
Cite this
Preparation of hydroxyapatite nanoparticles applying the micro chemical process. / Fujii, Eiji; Kawabata, Koji; Nakazaki, Yoshiaki; Tanizawa, Yuji; Matsumoto, Akihiro; Shirosaki, Yuki; Hayakawa, Satoshi; Osaka, Akiyoshi.
Ceramic Transactions. Vol. 218 2010. p. 185-190 (Ceramic Transactions; Vol. 218).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Preparation of hydroxyapatite nanoparticles applying the micro chemical process
AU - Fujii, Eiji
AU - Kawabata, Koji
AU - Nakazaki, Yoshiaki
AU - Tanizawa, Yuji
AU - Matsumoto, Akihiro
AU - Shirosaki, Yuki
AU - Hayakawa, Satoshi
AU - Osaka, Akiyoshi
PY - 2010
Y1 - 2010
N2 - A micro-chemical process was applied to prepare nanometer-size hydroxy apatite (HA) particles with various shapes and sizes so as to provide high surface activities, where solutions of reagent-grade calcium nitrate tetrahydrate and diammonium hydrogen phosphate were introduced in a micro reactor. The particles were characterized by X-ray diffractometry, transmission electron microscopy, or inductively coupled plasma photometry. Particle size and shape were dependent on not only pH and concentration of the mixing solutions but also the flow rate. Dilute solutions containing 3 mM Ca(II) and 5 mM P(V) yielded spherical HA particles, whose average particle size increased from about 3 nm to 40 nm as the flow rate increased from 0.3 to 3 ml·min -1, where pH and the temperature of the reaction system were respectively maintained at 10 and at 40°C. Concentrated solutions with 50 mM Ca(II) and 30 mM P(V) yielded rectangular plate-like HA particles, 300 nm long and 50 nm wide, when pH was kept at 8, while agglomerations of smaller HA particles of about 20-50 nm were obtained when pH was kept at 10.
AB - A micro-chemical process was applied to prepare nanometer-size hydroxy apatite (HA) particles with various shapes and sizes so as to provide high surface activities, where solutions of reagent-grade calcium nitrate tetrahydrate and diammonium hydrogen phosphate were introduced in a micro reactor. The particles were characterized by X-ray diffractometry, transmission electron microscopy, or inductively coupled plasma photometry. Particle size and shape were dependent on not only pH and concentration of the mixing solutions but also the flow rate. Dilute solutions containing 3 mM Ca(II) and 5 mM P(V) yielded spherical HA particles, whose average particle size increased from about 3 nm to 40 nm as the flow rate increased from 0.3 to 3 ml·min -1, where pH and the temperature of the reaction system were respectively maintained at 10 and at 40°C. Concentrated solutions with 50 mM Ca(II) and 30 mM P(V) yielded rectangular plate-like HA particles, 300 nm long and 50 nm wide, when pH was kept at 8, while agglomerations of smaller HA particles of about 20-50 nm were obtained when pH was kept at 10.
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M3 - Conference contribution
SN - 9780470905487
VL - 218
T3 - Ceramic Transactions
SP - 185
EP - 190
BT - Ceramic Transactions
ER -