Preparation of hydroxyapatite-alginate gels as a carrier for controlled release of paclitaxel

T. Yoshioka, T. Ikoma, A. Monkawa, S. Yunoki, T. Abe, M. Sakane, J. Tanaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

Original languageEnglish
Pages (from-to)1053-1056
Number of pages4
JournalKey Engineering Materials
Volume330-332 II
DOIs
Publication statusPublished - Jan 1 2007
Externally publishedYes

Keywords

  • Anti-cancer drug
  • Drug delivery system (DOS)
  • Hydroxyapatite (HAp)
  • Paclitaxel (Taxol)
  • Sodium alginate
  • Spray-dry

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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