Preparation of hydroxyapatite-alginate gels as a carrier for controlled release of paclitaxel

T. Yoshioka; T. Ikoma; A. Monkawa; S. Yunoki; T. Abe; M. Sakane; J. Tanaka

doi:10.4028/0-87849-422-7.1053

Preparation of hydroxyapatite-alginate gels as a carrier for controlled release of paclitaxel

T. Yoshioka, T. Ikoma, A. Monkawa, S. Yunoki, T. Abe, M. Sakane, J. Tanaka

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca²⁺-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

Original language	English
Pages (from-to)	1053-1056
Number of pages	4
Journal	Key Engineering Materials
Volume	330-332 II
DOIs	https://doi.org/10.4028/0-87849-422-7.1053
Publication status	Published - Jan 1 2007
Externally published	Yes

Keywords

Anti-cancer drug
Drug delivery system (DOS)
Hydroxyapatite (HAp)
Paclitaxel (Taxol)
Sodium alginate
Spray-dry

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4028/0-87849-422-7.1053

Cite this

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abstract = "Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.",

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T1 - Preparation of hydroxyapatite-alginate gels as a carrier for controlled release of paclitaxel

AU - Yoshioka, T.

AU - Ikoma, T.

AU - Monkawa, A.

AU - Yunoki, S.

AU - Abe, T.

AU - Sakane, M.

AU - Tanaka, J.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

AB - Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The spray-drying technique was employed for loading the paclitaxel into spherical HAp microparticles with 1 to 20 μm in diameter. The microparticles loaded with 2.4 or 7.3wt% of paclitaxel were then mixed with sodium alginate, which was followed by Ca2+-mediated gelation. The compressive strength of the HAp-alginate gels and the release of paclitaxel from the gels in a medium were investigated in vitro. The alginate matrix was effective for the achievement of controlled release of anti-cancer drugs.

KW - Anti-cancer drug

KW - Drug delivery system (DOS)

KW - Hydroxyapatite (HAp)

KW - Paclitaxel (Taxol)

KW - Sodium alginate

KW - Spray-dry

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JO - Key Engineering Materials

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Preparation of hydroxyapatite-alginate gels as a carrier for controlled release of paclitaxel

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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