Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta

Takahito Yagi, Michiko Sato, Yasumoto Nakazawa, Kimie Tanaka, Masataka Sata, Kenji Itoh, Yoshihide Takagi, Tetsuo Asakura

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Silk fibroin fiber has a long history of use in sutures because of its high strength and toughness. In the work reported in this paper, small-diameter vascular grafts 1.5 mm in diameter and 10 mm in length were prepared by coating a double-raschel knitted silk fiber graft with silk fibroin aqueous solution containing poly(ethylene glycol diglycidyl ether) as a cross-linking agent. The most important character of silk fibroin graft is remodeling, which is never observed for polyester fiber or expanded polytetrafluoroethylene grafts. The double-raschel knitted silk fiber graft with coating has sufficient physical strength and protects the ladder from the end in the implantation process. The coating also gives protection against leakage of blood from the graft, and elasticity to the graft. Eight weeks after implantation of the grafts in rat abdominal aorta, early formation of thrombosis was avoided.

Original languageEnglish
Pages (from-to)89-99
Number of pages11
JournalJournal of Artificial Organs
Volume14
Issue number2
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Silk
Abdominal Aorta
Grafts
Blood Vessels
Rats
Transplants
Fibroins
Fibers
Coatings
Polyesters
Elasticity
Ladders
Polytetrafluoroethylene
Polytetrafluoroethylenes
Sutures
Polyethylene glycols
Toughness
Ethers
Thrombosis
Blood

Keywords

  • Double-raschel knitting
  • Silk fibroin fiber
  • Small-diameter vascular graft

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta. / Yagi, Takahito; Sato, Michiko; Nakazawa, Yasumoto; Tanaka, Kimie; Sata, Masataka; Itoh, Kenji; Takagi, Yoshihide; Asakura, Tetsuo.

In: Journal of Artificial Organs, Vol. 14, No. 2, 06.2011, p. 89-99.

Research output: Contribution to journalArticle

Yagi, Takahito ; Sato, Michiko ; Nakazawa, Yasumoto ; Tanaka, Kimie ; Sata, Masataka ; Itoh, Kenji ; Takagi, Yoshihide ; Asakura, Tetsuo. / Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta. In: Journal of Artificial Organs. 2011 ; Vol. 14, No. 2. pp. 89-99.
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