Preparation of apatite microsphere with nano-size pores on the surface via salt-assisted ultrasonic spray-pyrolysis technique and its drug release behavior

Y. Kawanobe, M. Honda, T. Konishi, M. Mizumoto, Y. Habuto, N. Kanzawa, T. Uchino, M. Aizawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To apply biodegradable calcium-phosphate microspheres as a carrier for drug delivery system (DDS), the hollow HAp and TCP microspheres were prepared by the ultrasonic spray-pyrolysis (USSP) technique. In the present work, we prepared the hollow bioceramics microspheres with nano-size pores on the surface via a salt-assisted USSP technique on the basis of previous findings. Diameters of the microspheres were in the range of 0.5 to 3.0 μm, and the nano-pores with the size of ∼50 nm were present on the surface of the microspheres. The loaded amount of the drug depended on the specific surface area (SSA) value of the microspheres; the washed powders derived from the NaCl concentration of 1.00 mol · dm-3 showed the greatest amounts of released drug among examined sample powders. The microspheres with nano-size pores on the surface showed a two-step drug release behavior.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalJournal of the Australian Ceramic Society
Volume47
Issue number1
Publication statusPublished - Mar 28 2011

Keywords

  • Apatite microsphere
  • Drug release
  • Ultrasonic spray-pyrolysis
  • Vancomycin

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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