Preparation of apatite microsphere with nano-size pores on the surface via salt-assisted ultrasonic spray-pyrolysis technique and its drug release behavior

Y. Kawanobe, M. Honda, T. Konishi, M. Mizumoto, Y. Habuto, N. Kanzawa, T. Uchino, M. Aizawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To apply biodegradable calcium-phosphate microspheres as a carrier for drug delivery system (DDS), the hollow HAp and TCP microspheres were prepared by the ultrasonic spray-pyrolysis (USSP) technique. In the present work, we prepared the hollow bioceramics microspheres with nano-size pores on the surface via a salt-assisted USSP technique on the basis of previous findings. Diameters of the microspheres were in the range of 0.5 to 3.0 μm, and the nano-pores with the size of ∼50 nm were present on the surface of the microspheres. The loaded amount of the drug depended on the specific surface area (SSA) value of the microspheres; the washed powders derived from the NaCl concentration of 1.00 mol · dm-3 showed the greatest amounts of released drug among examined sample powders. The microspheres with nano-size pores on the surface showed a two-step drug release behavior.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalJournal of the Australian Ceramic Society
Volume47
Issue number1
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Apatites
Spray pyrolysis
Apatite
Microspheres
Pore size
Salts
Ultrasonics
Pharmaceutical Preparations
Powders
Bioceramics
Calcium phosphate
Specific surface area

Keywords

  • Apatite microsphere
  • Drug release
  • Ultrasonic spray-pyrolysis
  • Vancomycin

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Preparation of apatite microsphere with nano-size pores on the surface via salt-assisted ultrasonic spray-pyrolysis technique and its drug release behavior. / Kawanobe, Y.; Honda, M.; Konishi, T.; Mizumoto, M.; Habuto, Y.; Kanzawa, N.; Uchino, T.; Aizawa, M.

In: Journal of the Australian Ceramic Society, Vol. 47, No. 1, 2011, p. 6-10.

Research output: Contribution to journalArticle

Kawanobe, Y. ; Honda, M. ; Konishi, T. ; Mizumoto, M. ; Habuto, Y. ; Kanzawa, N. ; Uchino, T. ; Aizawa, M. / Preparation of apatite microsphere with nano-size pores on the surface via salt-assisted ultrasonic spray-pyrolysis technique and its drug release behavior. In: Journal of the Australian Ceramic Society. 2011 ; Vol. 47, No. 1. pp. 6-10.
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