Preparation of alkenyl sulfides and enamines by alkylidenation of carboxylic acid derivatives

Kazuhiko Takai, Osamu Fujimura, Yasutaka Kataoka, Kiitiro Utimoto

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Treatment of S-alkyl thioesters with a reagent prepared from RCHBr2, Zn, TiCl4, and TMEDA in THF at 25°C gives Z-alkenyl sulfides selectively in good to excellent yields. Using the alkylidenation method, ketene dithioacetals and enamines are produced from 1,3-dithian-2-one and amides, respectively.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalTetrahedron Letters
Issue number2
Publication statusPublished - 1989
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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