Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

Tomohiko Yoshioka, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane (γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.

Original languageEnglish
Pages (from-to)2889-2894
Number of pages6
JournalBiomaterials
Volume24
Issue number17
DOIs
Publication statusPublished - Aug 2003

Keywords

  • Alginic acid
  • Blood compatibility
  • Blood-clotting time
  • Platelet adhesion
  • Stainless steel
  • γ-Aminopropyltriethoxysilane

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Fingerprint Dive into the research topics of 'Preparation of alginic acid layers on stainless-steel substrates for biomedical applications'. Together they form a unique fingerprint.

  • Cite this