Abstract
Xanthine (Xan) and oxanine (Oxa) are the major deamination products of guanine formed by the treatment with nitrogen oxides (e.g., NO and HNO2). In this study, 2'-deoxyribonucleoside 5'-triphosphates of Xan and Oxa were prepared by the NaNO2 treatment of dGTP. These modified nucleotides were incorporated into oligonucleotides by DNA polymerase reactions. The repair activities of various DNA N-glycosylases for Xan and Oxa were examined using these substrates.
Original language | English |
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Pages (from-to) | 87-88 |
Number of pages | 2 |
Journal | Nucleic acids symposium series |
Issue number | 44 |
DOIs | |
Publication status | Published - 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)