Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite

Yuki Shirosaki, Yasuyo Tsukatani, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticlepeer-review

Abstract

Chitosan is a cationic polymer that forms polymerized membranes upon reaction with anionic polymers. Chitosan−carboxymethyl cellulose (CMC) capsules are drug delivery carrier candidates whose mechanical strength and permeability must be controlled to achieve sustained release. In this study, the capsules were prepared from chitosan−γ-glycidoxypropyltrimethoxysilane (GPTMS)−CMC. The mechanical stability of the capsules was improved by crosslinking the chitosan with GPTMS. The capsules were then coated with hydroxyapatite (HAp) by alternately soaking them in calcium chloride solution and disodium hydrogen phosphate solution to prevent rapid initial drug release. Cytochrome C (CC), as a model drug, was introduced into the capsules via two routes, impregnation and injection, and then the CC released from the capsules was examined. HAp was found to be deposited on the internal and external surfaces of the capsules. The amount of CC introduced, and the release rate were reduced by the HAp coating. The injection method was found to result in the greatest CC loading.

Original languageEnglish
Article number1111
JournalPharmaceutics
Volume14
Issue number5
DOIs
Publication statusPublished - May 2022

Keywords

  • capsule
  • chitosan–siloxane hybrid
  • drug release
  • hydroxyapatite coating

ASJC Scopus subject areas

  • Pharmaceutical Science

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