Preparation and characterization of porous scaffolds consisted of hydroxyapatite, polysaccharides and collagen for cartilage tissue engineering

Takuro Adegawa, Yoshimi Ohyabu, Toshimasa Uemura, Tomohiko Yoshioka, Kazuo Shinozaki, Junzo Tanaka

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Porous scaffolds, consisted of hydroxyapatite (HAp), chondroitinsulfate (ChS) and collagen, were prepared by freeze-drying technique. HAp/ChS composite particles were incorporated into a collagen matrix. Scanning electron microscope (SEM) observations showed that the porous scaffolds involved interconnected pores whose size was 80-200 μm in diameter. The HAp/ChS particles were homogeneously distributed in the collagen matrix. Surface area of the scaffolds was increased by the incorporation of the particles. Compression tests in phosphate buffer saline indicated that the porous scaffolds had elastic property and had larger compressive modulus than the pure collagen scaffold. The porous scaffolds obtained in this study could be useful for a cartilage tissue engineering.

Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalKey Engineering Materials
Volume396-398
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Cartilage
  • Chondroitinsulfate
  • Collagen
  • Hydroxyapatite
  • Polysaccharide
  • Scaffold

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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