Preoperative use of alpha-1 receptor blockers in male patients undergoing extracorporeal shock wave lithotripsy for a ureteral calculus

Takashi Yoshioka, Kenji Omae, Tatsushi Kawada, Yosuke Inoue, Morito Sugimoto, Tadashi Oeda, Shinya Uehara, Motoo Araki, Shunichi Fukuhara

Research output: Contribution to journalArticlepeer-review

Abstract

In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalActa medica Okayama
Volume74
Issue number4
Publication statusPublished - 2020

Keywords

  • Adrenergic alpha-1 receptor antagonists
  • Extracorporeal shockwave therapy
  • Urolithiasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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