Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection

Akihiro Matsumi, Ryuta Takenaka, Chihiro Ando, Yuki Sato, Kensuke Takei, Eriko Yasutomi, Shotaro Okanoue, Shohei Oka, Daisuke Kawai, Junro Kataoka, Koji Takemoto, Hirofumi Tsugeno, Shigeatsu Fujiki, Yoshiro Kawahara

Research output: Contribution to journalArticle

Abstract

Background: ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. Aims: To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary function tests. Methods: A total of 978 patients with gastric tumors who had received pulmonary function tests were treated by ESD between June 2006 and May 2014. Pulmonary function tests were assessed using a spirometer. The patients were categorized into four groups according to the predicted vital capacity (%VC) and forced expiratory volume in 1 s as a percentage of forced vital capacity (FEV1.0%): normal; restrictive pulmonary dysfunction; obstructive; and mixed. The factors associated with aspiration pneumonia were retrospectively analyzed. Results: Among the 268 cases with abnormal pulmonary function, 10 cases (3.7%) developed aspiration pneumonia. On the other hand, 7 cases (1.0%) with normal pulmonary function developed pneumonia. There was a significant correlation between pulmonary function and aspiration pneumonia (p = 0.010). When the pulmonary function cases were stratified into subgroups, 2.5% of cases with obstructive pulmonary dysfunction developed pneumonia, 5.5% with restrictive and 5.3% with mixed. By logistic regression analysis, pulmonary function, the presence of cerebral vascular disease, and procedure time were identified as significant independent risk factors associated with aspiration pneumonia. The odds ratios for pulmonary function, cerebral vascular disease, and procedure time were 3.6, 5.1, and 5.2, respectively. Conclusions: Preoperative pulmonary function tests may be useful markers to evaluate the risk for aspiration pneumonia after gastric ESD.

Original languageEnglish
Pages (from-to)3084-3090
Number of pages7
JournalDigestive Diseases and Sciences
Volume62
Issue number11
DOIs
Publication statusPublished - Nov 1 2017
Externally publishedYes

Keywords

  • Aspiration pneumonia
  • Complication
  • Endoscopic submucosal dissection
  • Gastric tumors
  • Pulmonary function test

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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  • Cite this

    Matsumi, A., Takenaka, R., Ando, C., Sato, Y., Takei, K., Yasutomi, E., Okanoue, S., Oka, S., Kawai, D., Kataoka, J., Takemoto, K., Tsugeno, H., Fujiki, S., & Kawahara, Y. (2017). Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection. Digestive Diseases and Sciences, 62(11), 3084-3090. https://doi.org/10.1007/s10620-017-4750-4