Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma

Yasuyuki Kobayashi, Takashi Saika, Yoshiyuki Miyaji, Michinao Saegusa, Ryoji Arata, Naoki Akebi, Tadasu Takenaka, Daisuke Manabe, Yasutomo Nasu, Hiromi Kumon

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the independent risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC). Methods: A total of 364 patients underwent nephroureterectomy (NUx) for UUT-UC between January 2005 and April 2009 in Okayama University and 17 affiliated hospitals. Patients with concomitant bladder cancer were excluded from the analysis. The clinicopathologic data for the remaining 288 patients with UUT-UC were retrospectively reviewed. Median follow-up after NUx was 20.2 months. The following variables were evaluated for any association with bladder recurrence: sex, age, tumor stage, tumor grade, venous invasion, lymphatic invasion, tumor location, multifocality, surgical modalities, time of ligation of the ureter, and preoperative urine cytology. The significance of each variable was tested univariately using the log-rank test. The simultaneous effects of multiple risk factors were estimated by multiple regression analysis using the Cox proportional hazards model. Results: Bladder recurrence occurred in 103 patients (35.8%). Median time to first bladder recurrence was 6.9 months. Significant risk factors for bladder recurrences on univariate analysis were tumor location (P = 0.046) and preoperative positive urine cytology (P <0.001). Multivariate analysis revealed that preoperative urine cytology positive was significant for bladder recurrence (HR: 1.977; 95% CI: 1.310-2.983, P = 0.001). Conclusion: Risk factor for subsequent development of bladder cancer after NUx was preoperative positive urine cytology.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalWorld Journal of Urology
Volume30
Issue number2
DOIs
Publication statusPublished - Apr 2012

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Urinary Tract
Urinary Bladder Neoplasms
Cell Biology
Urinary Bladder
Urine
Carcinoma
Recurrence
Neoplasms
Ureter
Proportional Hazards Models
Ligation
Multivariate Analysis
Regression Analysis

Keywords

  • Bladder recurrence
  • Nephroureterectomy
  • Upper urinary tract
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma. / Kobayashi, Yasuyuki; Saika, Takashi; Miyaji, Yoshiyuki; Saegusa, Michinao; Arata, Ryoji; Akebi, Naoki; Takenaka, Tadasu; Manabe, Daisuke; Nasu, Yasutomo; Kumon, Hiromi.

In: World Journal of Urology, Vol. 30, No. 2, 04.2012, p. 271-275.

Research output: Contribution to journalArticle

Kobayashi, Yasuyuki ; Saika, Takashi ; Miyaji, Yoshiyuki ; Saegusa, Michinao ; Arata, Ryoji ; Akebi, Naoki ; Takenaka, Tadasu ; Manabe, Daisuke ; Nasu, Yasutomo ; Kumon, Hiromi. / Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma. In: World Journal of Urology. 2012 ; Vol. 30, No. 2. pp. 271-275.
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abstract = "Purpose: To determine the independent risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC). Methods: A total of 364 patients underwent nephroureterectomy (NUx) for UUT-UC between January 2005 and April 2009 in Okayama University and 17 affiliated hospitals. Patients with concomitant bladder cancer were excluded from the analysis. The clinicopathologic data for the remaining 288 patients with UUT-UC were retrospectively reviewed. Median follow-up after NUx was 20.2 months. The following variables were evaluated for any association with bladder recurrence: sex, age, tumor stage, tumor grade, venous invasion, lymphatic invasion, tumor location, multifocality, surgical modalities, time of ligation of the ureter, and preoperative urine cytology. The significance of each variable was tested univariately using the log-rank test. The simultaneous effects of multiple risk factors were estimated by multiple regression analysis using the Cox proportional hazards model. Results: Bladder recurrence occurred in 103 patients (35.8{\%}). Median time to first bladder recurrence was 6.9 months. Significant risk factors for bladder recurrences on univariate analysis were tumor location (P = 0.046) and preoperative positive urine cytology (P <0.001). Multivariate analysis revealed that preoperative urine cytology positive was significant for bladder recurrence (HR: 1.977; 95{\%} CI: 1.310-2.983, P = 0.001). Conclusion: Risk factor for subsequent development of bladder cancer after NUx was preoperative positive urine cytology.",
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AU - Kobayashi, Yasuyuki

AU - Saika, Takashi

AU - Miyaji, Yoshiyuki

AU - Saegusa, Michinao

AU - Arata, Ryoji

AU - Akebi, Naoki

AU - Takenaka, Tadasu

AU - Manabe, Daisuke

AU - Nasu, Yasutomo

AU - Kumon, Hiromi

PY - 2012/4

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N2 - Purpose: To determine the independent risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC). Methods: A total of 364 patients underwent nephroureterectomy (NUx) for UUT-UC between January 2005 and April 2009 in Okayama University and 17 affiliated hospitals. Patients with concomitant bladder cancer were excluded from the analysis. The clinicopathologic data for the remaining 288 patients with UUT-UC were retrospectively reviewed. Median follow-up after NUx was 20.2 months. The following variables were evaluated for any association with bladder recurrence: sex, age, tumor stage, tumor grade, venous invasion, lymphatic invasion, tumor location, multifocality, surgical modalities, time of ligation of the ureter, and preoperative urine cytology. The significance of each variable was tested univariately using the log-rank test. The simultaneous effects of multiple risk factors were estimated by multiple regression analysis using the Cox proportional hazards model. Results: Bladder recurrence occurred in 103 patients (35.8%). Median time to first bladder recurrence was 6.9 months. Significant risk factors for bladder recurrences on univariate analysis were tumor location (P = 0.046) and preoperative positive urine cytology (P <0.001). Multivariate analysis revealed that preoperative urine cytology positive was significant for bladder recurrence (HR: 1.977; 95% CI: 1.310-2.983, P = 0.001). Conclusion: Risk factor for subsequent development of bladder cancer after NUx was preoperative positive urine cytology.

AB - Purpose: To determine the independent risk factors of bladder recurrence in patients with upper urinary tract urothelial carcinoma (UUT-UC). Methods: A total of 364 patients underwent nephroureterectomy (NUx) for UUT-UC between January 2005 and April 2009 in Okayama University and 17 affiliated hospitals. Patients with concomitant bladder cancer were excluded from the analysis. The clinicopathologic data for the remaining 288 patients with UUT-UC were retrospectively reviewed. Median follow-up after NUx was 20.2 months. The following variables were evaluated for any association with bladder recurrence: sex, age, tumor stage, tumor grade, venous invasion, lymphatic invasion, tumor location, multifocality, surgical modalities, time of ligation of the ureter, and preoperative urine cytology. The significance of each variable was tested univariately using the log-rank test. The simultaneous effects of multiple risk factors were estimated by multiple regression analysis using the Cox proportional hazards model. Results: Bladder recurrence occurred in 103 patients (35.8%). Median time to first bladder recurrence was 6.9 months. Significant risk factors for bladder recurrences on univariate analysis were tumor location (P = 0.046) and preoperative positive urine cytology (P <0.001). Multivariate analysis revealed that preoperative urine cytology positive was significant for bladder recurrence (HR: 1.977; 95% CI: 1.310-2.983, P = 0.001). Conclusion: Risk factor for subsequent development of bladder cancer after NUx was preoperative positive urine cytology.

KW - Bladder recurrence

KW - Nephroureterectomy

KW - Upper urinary tract

KW - Urothelial carcinoma

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