Preoperative concurrent chemoradiotherapy with cisplatin and docetaxel in patients with locally advanced non-small-cell lung cancer

H. Katayama, H. Ueoka, K. Kiura, M. Tabata, T. Kozuki, M. Tanimoto, T. Fujiwara, N. Tanaka, H. Date, M. Aoe, N. Shimizu, M. Takemoto, Y. Hiraki

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48 Citations (Scopus)

Abstract

The objective of this study was to assess the feasibility and effectiveness of an induction chemoradiotherapy regimen followed by surgery in patients with locally advanced non-small-cell lung cancer (LA-NSCLC). A total of 22 patients with LA-NSCLC were treated with induction chemoradiotherapy consisting of cisplatin (40 mg m-2) and docetaxel (40 mg m-2) given on days 1, 8, 29 and 36 plus concurrent thoracic irradiation at a dose of 40-60 Gy (2 Gy fraction-1 day-1). Surgical resection was performed within 6 weeks after completion of induction therapy. Objective response to the induction therapy was obtained in 16 patients (73%). In all, 20 patients (91%) underwent surgery and complete resection was achieved in 19 patients (86%). Pathological downstaging and pathological complete response were obtained in 14 (6496) and five (23%) patients, respectively. With a median follow-up period of 32 months, the calculated 3-year overall and progression-free survival rates were 66 and 61%, respectively. It is noteworthy that the 3-year overall survival rate in 14 patients achieving pathological downstaging was extremely high (93%). Toxicity was manageable with standard approaches. No treatment-related deaths occurred. This combined modality treatment is feasible and highly effective in patients with LA-NSCLC. The results warrant further large-scale study to confirm the effectiveness of this regimen.

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalBritish Journal of Cancer
Volume90
Issue number5
DOIs
Publication statusPublished - Mar 8 2004

Keywords

  • Cisplatin
  • Docetaxel
  • Induction chemoradiotherapy
  • Non-small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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