Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor

Fumiyo Higaki, Yoshihiro Okumura, Shuhei Sato, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Shiro Akaki, Toshihide Tsuda, Susumu Kanazawa

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression. Methods: We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 0-3 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUV max were determined using receiver-operating characteristic (ROC) analysis. Results: The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity. Conclusions: The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalAnnals of Nuclear Medicine
Volume22
Issue number3
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Radio
Lung
Neoplasms
ROC Curve
Intravenous Administration
Contrast Media
Positron Emission Tomography Computed Tomography
Thorax
Tomography

Keywords

  • Local tumor progression
  • Lung tumor
  • PET/CT
  • Radio frequency ablation
  • SUV

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor. / Higaki, Fumiyo; Okumura, Yoshihiro; Sato, Shuhei; Hiraki, Takao; Gobara, Hideo; Mimura, Hidefumi; Akaki, Shiro; Tsuda, Toshihide; Kanazawa, Susumu.

In: Annals of Nuclear Medicine, Vol. 22, No. 3, 04.2008, p. 157-163.

Research output: Contribution to journalArticle

Higaki, Fumiyo ; Okumura, Yoshihiro ; Sato, Shuhei ; Hiraki, Takao ; Gobara, Hideo ; Mimura, Hidefumi ; Akaki, Shiro ; Tsuda, Toshihide ; Kanazawa, Susumu. / Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor. In: Annals of Nuclear Medicine. 2008 ; Vol. 22, No. 3. pp. 157-163.
@article{2262f3cddff24654a8adf028530ec022,
title = "Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor",
abstract = "Objective: The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression. Methods: We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 0-3 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUV max were determined using receiver-operating characteristic (ROC) analysis. Results: The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8{\%} sensitivity and 85.7-90.5{\%} specificity. Conclusions: The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.",
keywords = "Local tumor progression, Lung tumor, PET/CT, Radio frequency ablation, SUV",
author = "Fumiyo Higaki and Yoshihiro Okumura and Shuhei Sato and Takao Hiraki and Hideo Gobara and Hidefumi Mimura and Shiro Akaki and Toshihide Tsuda and Susumu Kanazawa",
year = "2008",
month = "4",
doi = "10.1007/s12149-007-0113-0",
language = "English",
volume = "22",
pages = "157--163",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor

AU - Higaki, Fumiyo

AU - Okumura, Yoshihiro

AU - Sato, Shuhei

AU - Hiraki, Takao

AU - Gobara, Hideo

AU - Mimura, Hidefumi

AU - Akaki, Shiro

AU - Tsuda, Toshihide

AU - Kanazawa, Susumu

PY - 2008/4

Y1 - 2008/4

N2 - Objective: The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression. Methods: We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 0-3 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUV max were determined using receiver-operating characteristic (ROC) analysis. Results: The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity. Conclusions: The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

AB - Objective: The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression. Methods: We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 0-3 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUV max were determined using receiver-operating characteristic (ROC) analysis. Results: The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity. Conclusions: The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

KW - Local tumor progression

KW - Lung tumor

KW - PET/CT

KW - Radio frequency ablation

KW - SUV

UR - http://www.scopus.com/inward/record.url?scp=44349098748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44349098748&partnerID=8YFLogxK

U2 - 10.1007/s12149-007-0113-0

DO - 10.1007/s12149-007-0113-0

M3 - Article

C2 - 18498029

AN - SCOPUS:44349098748

VL - 22

SP - 157

EP - 163

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 3

ER -