Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor

Fumiyo Higaki, Yoshihiro Okumura, Shuhei Sato, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Shiro Akaki, Toshihide Tsuda, Susumu Kanazawa

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40 Citations (Scopus)

Abstract

Objective: The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression. Methods: We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 0-3 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUV max were determined using receiver-operating characteristic (ROC) analysis. Results: The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity. Conclusions: The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalAnnals of Nuclear Medicine
Volume22
Issue number3
DOIs
Publication statusPublished - Apr 2008

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Keywords

  • Local tumor progression
  • Lung tumor
  • PET/CT
  • Radio frequency ablation
  • SUV

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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