Preliminary experimental evaluation of temporary segmental hepatic venous occlusion

angiographic, pathologic, and scintigraphic findings.

Susumu Kanazawa, K. C. Wright, L. P. Kasi, C. Charnsangavej, S. Wallace

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

PURPOSE: Pigs were used to evaluate temporary segmental hepatic venous occlusion as a means of improving the selective delivery of therapeutic agents within the liver. MATERIALS AND METHODS: Hepatic angiography and scintigraphy were performed alone and in combination with hepatic venous occlusion. RESULTS: Arteriograms obtained during venous obstruction demonstrated a greater number of peripheral arterial branches in the occluded area compared with the nonoccluded areas. A prolonged hepatogram showing hepatofugal opacification of the portal branches was observed in the occluded area. Microscopically, mild congestion of the sinusoids and central veins was seen immediately after 60-minute occlusion, but these changes were not evident 2 hours after balloon deflation. Severe congestion and focal hemorrhage were found in the occluded segment of the liver 2 hours after 90-minute venous occlusion. When the right or left hepatic vein was occluded during hepatic arterial infusion of technetium-99m macroaggregated albumin, there was a significant (P <or = .05) increase in the amount of radioactivity measured in the obstructed segment and a significant (P <or = .05) decrease in that found in the nonoccluded regions. CONCLUSION: These results indicate that temporary segmental hepatic vein occlusion is safe for up to 60 minutes and may be clinically applicable as a means of improving the therapeutic index of agents within the liver when they are administered via concomitant hepatic arterial infusion.

Original languageEnglish
Pages (from-to)759-766
Number of pages8
JournalJournal of Vascular and Interventional Radiology
Volume4
Issue number6
Publication statusPublished - Nov 1993

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Liver
Hepatic Veins
Technetium
Radionuclide Imaging
Radioactivity
Albumins
Veins
Angiography
Swine
Hemorrhage
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Preliminary experimental evaluation of temporary segmental hepatic venous occlusion : angiographic, pathologic, and scintigraphic findings. / Kanazawa, Susumu; Wright, K. C.; Kasi, L. P.; Charnsangavej, C.; Wallace, S.

In: Journal of Vascular and Interventional Radiology, Vol. 4, No. 6, 11.1993, p. 759-766.

Research output: Contribution to journalArticle

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