Preliminary Experimental Evaluation of Temporary Segmental Hepatic Venous Occlusion: Angiographic, Pathologic, and Scintigraphic Findings

Susumu Kanazawa

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    Pigs were used to evaluate temporary segmental hepatic venous occlusion as a means of improving the selective delivery of therapeutic agents within the liver. Hepatic angiography and scintigraphy were performed alone and in combination with hepatic venous occlusion. Arteriograms obtained during venous obstruction demonstrated a greater number of peripheral arterial branches in the occluded area compared with the nonoccluded areas. A prolonged hepatogram showing hepatofugal opacification of the portal branches was observed in the occluded area. Microscopically, mild congestion of the sinusoids and central veins was seen immediately after 60-minute occlusion, but these changes were not evident 2 hours after balloon deflation. Severe congestion and focal hemorrhage were found in the occluded segment of the liver 2 hours after 90-minute venous occlusion. When the right or left hepatic vein was occluded during hepatic arterial infusion of technetium-99m macroaggregated albumin, there was a significant (P ≤ .05) increase in the amount of radioactivity measured in the obstructed segment and a significant (P ≤ .05) decrease in that found in the nonoccluded regions. These results indicate that temporary segmental hepatic vein occlusion is safe for up to 60 minutes and may be clinically applicable as a means of improving the therapeutic index of agents within the liver when they are administered via concomitant hepatic arterial infusion.

    Original languageEnglish
    Pages (from-to)759-766
    Number of pages8
    JournalJournal of Vascular and Interventional Radiology
    Volume4
    Issue number6
    DOIs
    Publication statusPublished - 1993

    Keywords

    • Hepatic arteries, chemotherapeutic infusion, 952.1266
    • Hepatic veins, stenosis or obstruction, 959.1269
    • Liver neoplasms, therapy, 761.1266
    • Liver, blood supply, 959.1269
    • MAA
    • macroaggregated albumin

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Cardiology and Cardiovascular Medicine

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