Pregnancy with anti-muSK-positive myasthenia gravis that was diagnosed during pregnancy: A case rport

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Anti-muscle-specific tyrosine kinase (MuSK)-positive myasthenia gravis (MG) has a late onset in the 4th decade of life and a poor response to med-ical treatment. Few cases of pregnancy with anti-MuSK-positive MG have been de-scribed. We report a case of pregnancy with anti-MuSK-positive MG that was diagnosed during pregnancy. CASE: A 46-year-old healthy primiparous woman was referred to Okayama Univer-73) sity Hospital at 23 weeks’ gestation because of anti-MuSK-positive MG that was diagnosed during pregnancy in the first trimester. Emergent cesarean section was performed at 30 weeks’ gestation because of severe preeclampsia and pre-crisis of MG. She received medication and plasmapheresis for hypertension and severe MG symptoms and was discharged on day 35 after delivery. The neonate had no symptoms of transient neonatal MG, and anti-MuSK antibody was positive at birth and then decreased to the normal range at 5 months old. CONCLUSION: Our case and previous reports indicate that pregnancy with anti-MuSK-positive MG might have the same or a relatively higher risk for the mother and neonate as compared with anti-AChR-positive MG. Multidisciplinary management throughout the perinatal period should be provided for pregnancy with anti-MuSK-positive MG.

Original languageEnglish
Pages (from-to)71-73
Number of pages3
JournalJournal of Reproductive Medicine
Volume64
Issue number1
Publication statusPublished - Jan 1 2019

Fingerprint

Myasthenia Gravis
Protein-Tyrosine Kinases
Pregnancy
Muscles
Neonatal Myasthenia Gravis
Newborn Infant
musk
Plasmapheresis
First Pregnancy Trimester
Pre-Eclampsia
Cesarean Section
Reference Values
Mothers
Parturition
Hypertension
Antibodies

Keywords

  • Acetylcholine receptor
  • AChR
  • Anti-idiotypic
  • Anti-IgG
  • Anti-muscle-specific tyrosine kinase antibody
  • Antibodies
  • Cesarean section
  • Cholinergic
  • Human
  • Muscle-specific kinase
  • MuSK protein
  • MUSK protein
  • Myasthenia gravis
  • Myasthenia gravis anti-skeletal muscle antibody
  • Preeclampsia
  • Receptor protein-tyrosine kinases
  • Receptors
  • Transient neonatal myasthenia gravis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

@article{f6e9d91e56c14bd2bc84a2115d41a14c,
title = "Pregnancy with anti-muSK-positive myasthenia gravis that was diagnosed during pregnancy: A case rport",
abstract = "BACKGROUND: Anti-muscle-specific tyrosine kinase (MuSK)-positive myasthenia gravis (MG) has a late onset in the 4th decade of life and a poor response to med-ical treatment. Few cases of pregnancy with anti-MuSK-positive MG have been de-scribed. We report a case of pregnancy with anti-MuSK-positive MG that was diagnosed during pregnancy. CASE: A 46-year-old healthy primiparous woman was referred to Okayama Univer-73) sity Hospital at 23 weeks’ gestation because of anti-MuSK-positive MG that was diagnosed during pregnancy in the first trimester. Emergent cesarean section was performed at 30 weeks’ gestation because of severe preeclampsia and pre-crisis of MG. She received medication and plasmapheresis for hypertension and severe MG symptoms and was discharged on day 35 after delivery. The neonate had no symptoms of transient neonatal MG, and anti-MuSK antibody was positive at birth and then decreased to the normal range at 5 months old. CONCLUSION: Our case and previous reports indicate that pregnancy with anti-MuSK-positive MG might have the same or a relatively higher risk for the mother and neonate as compared with anti-AChR-positive MG. Multidisciplinary management throughout the perinatal period should be provided for pregnancy with anti-MuSK-positive MG.",
keywords = "Acetylcholine receptor, AChR, Anti-idiotypic, Anti-IgG, Anti-muscle-specific tyrosine kinase antibody, Antibodies, Cesarean section, Cholinergic, Human, Muscle-specific kinase, MuSK protein, MUSK protein, Myasthenia gravis, Myasthenia gravis anti-skeletal muscle antibody, Preeclampsia, Receptor protein-tyrosine kinases, Receptors, Transient neonatal myasthenia gravis",
author = "Hisashi Masuyama and Izumi Suzui and Kei Hayata and Yousuke Washio and Junko Yoshimoto and Yuji Hiramatsu",
year = "2019",
month = "1",
day = "1",
language = "English",
volume = "64",
pages = "71--73",
journal = "The Journal of reproductive medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "1",

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TY - JOUR

T1 - Pregnancy with anti-muSK-positive myasthenia gravis that was diagnosed during pregnancy

T2 - A case rport

AU - Masuyama, Hisashi

AU - Suzui, Izumi

AU - Hayata, Kei

AU - Washio, Yousuke

AU - Yoshimoto, Junko

AU - Hiramatsu, Yuji

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND: Anti-muscle-specific tyrosine kinase (MuSK)-positive myasthenia gravis (MG) has a late onset in the 4th decade of life and a poor response to med-ical treatment. Few cases of pregnancy with anti-MuSK-positive MG have been de-scribed. We report a case of pregnancy with anti-MuSK-positive MG that was diagnosed during pregnancy. CASE: A 46-year-old healthy primiparous woman was referred to Okayama Univer-73) sity Hospital at 23 weeks’ gestation because of anti-MuSK-positive MG that was diagnosed during pregnancy in the first trimester. Emergent cesarean section was performed at 30 weeks’ gestation because of severe preeclampsia and pre-crisis of MG. She received medication and plasmapheresis for hypertension and severe MG symptoms and was discharged on day 35 after delivery. The neonate had no symptoms of transient neonatal MG, and anti-MuSK antibody was positive at birth and then decreased to the normal range at 5 months old. CONCLUSION: Our case and previous reports indicate that pregnancy with anti-MuSK-positive MG might have the same or a relatively higher risk for the mother and neonate as compared with anti-AChR-positive MG. Multidisciplinary management throughout the perinatal period should be provided for pregnancy with anti-MuSK-positive MG.

AB - BACKGROUND: Anti-muscle-specific tyrosine kinase (MuSK)-positive myasthenia gravis (MG) has a late onset in the 4th decade of life and a poor response to med-ical treatment. Few cases of pregnancy with anti-MuSK-positive MG have been de-scribed. We report a case of pregnancy with anti-MuSK-positive MG that was diagnosed during pregnancy. CASE: A 46-year-old healthy primiparous woman was referred to Okayama Univer-73) sity Hospital at 23 weeks’ gestation because of anti-MuSK-positive MG that was diagnosed during pregnancy in the first trimester. Emergent cesarean section was performed at 30 weeks’ gestation because of severe preeclampsia and pre-crisis of MG. She received medication and plasmapheresis for hypertension and severe MG symptoms and was discharged on day 35 after delivery. The neonate had no symptoms of transient neonatal MG, and anti-MuSK antibody was positive at birth and then decreased to the normal range at 5 months old. CONCLUSION: Our case and previous reports indicate that pregnancy with anti-MuSK-positive MG might have the same or a relatively higher risk for the mother and neonate as compared with anti-AChR-positive MG. Multidisciplinary management throughout the perinatal period should be provided for pregnancy with anti-MuSK-positive MG.

KW - Acetylcholine receptor

KW - AChR

KW - Anti-idiotypic

KW - Anti-IgG

KW - Anti-muscle-specific tyrosine kinase antibody

KW - Antibodies

KW - Cesarean section

KW - Cholinergic

KW - Human

KW - Muscle-specific kinase

KW - MuSK protein

KW - MUSK protein

KW - Myasthenia gravis

KW - Myasthenia gravis anti-skeletal muscle antibody

KW - Preeclampsia

KW - Receptor protein-tyrosine kinases

KW - Receptors

KW - Transient neonatal myasthenia gravis

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M3 - Article

AN - SCOPUS:85060739998

VL - 64

SP - 71

EP - 73

JO - The Journal of reproductive medicine

JF - The Journal of reproductive medicine

SN - 0024-7758

IS - 1

ER -