Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis

Eisho Yoshikawa, Yutaka Matsuoka, Hidenori Yamasue, Masatoshi Inagaki, Tomohito Nakano, Tatsuo Akechi, Makoto Kobayakawa, Maiko Fujimori, Naoki Nakaya, Nobuya Akizuki, Shigeru Imoto, Koji Murakami, Kiyoto Kasai, Yosuke Uchitomi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Major and minor depressive episodes in cancer patients are frequent and are frequently seen as the first depressive episode in a patient's life. However, the neurological basis of these depressive episodes remains largely unknown. Methods: Subjects were 51 breast cancer survivors (BCS) who had no history of any depressive episode before the cancer diagnosis (11 BCS with a history of a first minor depressive episode after cancer diagnosis, 11 BCS with a history of a first major depressive episode after cancer diagnosis, and 29 BCS with no history of any depressive episode after cancer diagnosis). We analyzed the prefrontal cortex (PFC) and amygdala volumes in a 1.5-Tesla Magnetic Resonance Imaging scanner. We characterized the structural correlates of depression using two complementary approaches. The first was voxel-based morphometry (VBM) that allowed us to scan the entire brain for reactive gray matter deficit. The second was classical volumetry focusing on the amygdala. Results: Voxel-based morphometry revealed no brain region, including PFC, for which volume was significantly different among the three groups. There were trend-level differences in the left amygdala volume in the manual tracing method among the three groups. The left amygdala volumes in the subjects with a first minor and/or major depressive episode were significantly smaller than in those with no history of any depressive episode. Conclusions: It might be suggested that amygdala volume was associated with a first minor and/or major depressive episode after cancer diagnosis.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalBiological Psychiatry
Volume59
Issue number8
DOIs
Publication statusPublished - Apr 15 2006
Externally publishedYes

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Amygdala
Prefrontal Cortex
Survivors
Breast Neoplasms
Neoplasms
Brain
Magnetic Resonance Imaging

Keywords

  • Amygdala
  • Depressive disorder
  • Magnetic resonance imaging
  • Prefrontal cortex (PFC)
  • Voxel-based morphometry (VBM)

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Yoshikawa, E., Matsuoka, Y., Yamasue, H., Inagaki, M., Nakano, T., Akechi, T., ... Uchitomi, Y. (2006). Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. Biological Psychiatry, 59(8), 707-712. https://doi.org/10.1016/j.biopsych.2005.08.018

Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. / Yoshikawa, Eisho; Matsuoka, Yutaka; Yamasue, Hidenori; Inagaki, Masatoshi; Nakano, Tomohito; Akechi, Tatsuo; Kobayakawa, Makoto; Fujimori, Maiko; Nakaya, Naoki; Akizuki, Nobuya; Imoto, Shigeru; Murakami, Koji; Kasai, Kiyoto; Uchitomi, Yosuke.

In: Biological Psychiatry, Vol. 59, No. 8, 15.04.2006, p. 707-712.

Research output: Contribution to journalArticle

Yoshikawa, E, Matsuoka, Y, Yamasue, H, Inagaki, M, Nakano, T, Akechi, T, Kobayakawa, M, Fujimori, M, Nakaya, N, Akizuki, N, Imoto, S, Murakami, K, Kasai, K & Uchitomi, Y 2006, 'Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis', Biological Psychiatry, vol. 59, no. 8, pp. 707-712. https://doi.org/10.1016/j.biopsych.2005.08.018
Yoshikawa, Eisho ; Matsuoka, Yutaka ; Yamasue, Hidenori ; Inagaki, Masatoshi ; Nakano, Tomohito ; Akechi, Tatsuo ; Kobayakawa, Makoto ; Fujimori, Maiko ; Nakaya, Naoki ; Akizuki, Nobuya ; Imoto, Shigeru ; Murakami, Koji ; Kasai, Kiyoto ; Uchitomi, Yosuke. / Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. In: Biological Psychiatry. 2006 ; Vol. 59, No. 8. pp. 707-712.
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