Preferential Expression of HSC70 Heat Shock mRNA in Gerbil Heart After Transient Brain Ischemia

Koji Abe, T. H. Lee, M. Aoki, Y. Nitta, S. Isoyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Inductions of mRNAs for heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 were examined in the cerebral cortex, cerebellum, heart, lung, kidney, and liver of gerbils after a 10-min transient forebrain ischemia. HSP70 mRNA was normally expressed in a small amount in the cerebellum, lung, and kidney, but was not expressed in the heart or liver in a detectable amount. A very small amount of HSP70 mRNA was also present in the cerebral cortex. HSC70 mRNA was normally present in all the organs examined with a variety in the amount. Eight hours after the cerebral ischemia, the level of HSP70 mRNA increased in the cerebral cortex, lung, and kidney. HSC70 mRNA levels also increased in all organs. However, the increase of HSC70 mRNA was remarkable in the heart. Transient cerebral ischemia caused subsequent hyperthermia. Treatment of gerbils with an artificial hyperthermia without cerebral ischemia increased the HSP70 and HSC70 mRNA levels as well. However, the HSC70 mRNA level in the heart after cerebral ischemia was much higher than that in the case with hyperthermic treatment. These results suggest that HSC70 mRNA was preferentially induced in the heart after transient forebrain ischemia that was not only due to the subsequent hyperthermia.

Original languageEnglish
Pages (from-to)1131-1135
Number of pages5
JournalJournal of Molecular and Cellular Cardiology
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 1993
Externally publishedYes

Fingerprint

Gerbillinae
Brain Ischemia
Shock
Hot Temperature
Messenger RNA
Cerebral Cortex
Fever
Prosencephalon
Kidney
Lung
Cerebellum
Ischemia
HSC70 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Liver
Transient Ischemic Attack

Keywords

  • Cerebral ischemia
  • Heart
  • Heat shock cognate protein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Molecular Biology

Cite this

Preferential Expression of HSC70 Heat Shock mRNA in Gerbil Heart After Transient Brain Ischemia. / Abe, Koji; Lee, T. H.; Aoki, M.; Nitta, Y.; Isoyama, S.

In: Journal of Molecular and Cellular Cardiology, Vol. 25, No. 10, 10.1993, p. 1131-1135.

Research output: Contribution to journalArticle

Abe, Koji ; Lee, T. H. ; Aoki, M. ; Nitta, Y. ; Isoyama, S. / Preferential Expression of HSC70 Heat Shock mRNA in Gerbil Heart After Transient Brain Ischemia. In: Journal of Molecular and Cellular Cardiology. 1993 ; Vol. 25, No. 10. pp. 1131-1135.
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