Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Takahiro Aoki; Hiroyuki Takahashi; Shiro Tanaka; Norio Shiba; Daiichiro Hasegawa; Shotaro Iwamoto; Kiminori Terui; Hiroshi Moritake; Hideki Nakayama; Akira Shimada; Katsuyoshi Koh; Hiroaki Goto; Yoshiyuki Kosaka; Akiko M. Saito; Keizo Horibe; Akitoshi Kinoshita; Akio Tawa; Takashi Taga; Souichi Adachi; Daisuke Tomizawa

doi:10.1111/bjh.16656

Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Takahiro Aoki, Hiroyuki Takahashi, Shiro Tanaka, Norio Shiba, Daiichiro Hasegawa, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, Katsuyoshi Koh, Hiroaki Goto, Yoshiyuki Kosaka, Akiko M. Saito, Keizo Horibe, Akitoshi Kinoshita, Akio Tawa, Takashi Taga, Souichi Adachi, Daisuke Tomizawa

University Hospital

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Abstract

The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0·011) and low frequency of relapse (P = 0·042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.

Original language	English
Pages (from-to)	176-180
Number of pages	5
Journal	British Journal of Haematology
Volume	193
Issue number	1
DOIs	https://doi.org/10.1111/bjh.16656
Publication status	Published - Apr 2021

Keywords

acute myeloid leukaemia
chemosensitivity
children
myelosuppression
neutropenia

ASJC Scopus subject areas

Hematology

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10.1111/bjh.16656

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Aoki, T., Takahashi, H., Tanaka, S., Shiba, N., Hasegawa, D., Iwamoto, S., Terui, K., Moritake, H., Nakayama, H., Shimada, A., Koh, K., Goto, H., Kosaka, Y., Saito, A. M., Horibe, K., Kinoshita, A., Tawa, A., Taga, T., Adachi, S., & Tomizawa, D. (2021). Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. British Journal of Haematology, 193(1), 176-180. https://doi.org/10.1111/bjh.16656

Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. / Aoki, Takahiro; Takahashi, Hiroyuki; Tanaka, Shiro; Shiba, Norio; Hasegawa, Daiichiro; Iwamoto, Shotaro; Terui, Kiminori; Moritake, Hiroshi; Nakayama, Hideki; Shimada, Akira; Koh, Katsuyoshi; Goto, Hiroaki; Kosaka, Yoshiyuki; Saito, Akiko M.; Horibe, Keizo; Kinoshita, Akitoshi; Tawa, Akio; Taga, Takashi; Adachi, Souichi; Tomizawa, Daisuke.

In: British Journal of Haematology, Vol. 193, No. 1, 04.2021, p. 176-180.

Research output: Contribution to journal › Article › peer-review

Aoki, T, Takahashi, H, Tanaka, S, Shiba, N, Hasegawa, D, Iwamoto, S, Terui, K, Moritake, H, Nakayama, H, Shimada, A, Koh, K, Goto, H, Kosaka, Y, Saito, AM, Horibe, K, Kinoshita, A, Tawa, A, Taga, T, Adachi, S & Tomizawa, D 2021, 'Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study', British Journal of Haematology, vol. 193, no. 1, pp. 176-180. https://doi.org/10.1111/bjh.16656

Aoki, Takahiro ; Takahashi, Hiroyuki ; Tanaka, Shiro ; Shiba, Norio ; Hasegawa, Daiichiro ; Iwamoto, Shotaro ; Terui, Kiminori ; Moritake, Hiroshi ; Nakayama, Hideki ; Shimada, Akira ; Koh, Katsuyoshi ; Goto, Hiroaki ; Kosaka, Yoshiyuki ; Saito, Akiko M. ; Horibe, Keizo ; Kinoshita, Akitoshi ; Tawa, Akio ; Taga, Takashi ; Adachi, Souichi ; Tomizawa, Daisuke. / Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. In: British Journal of Haematology. 2021 ; Vol. 193, No. 1. pp. 176-180.

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abstract = "The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0·011) and low frequency of relapse (P = 0·042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.",

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AU - Terui, Kiminori

AU - Moritake, Hiroshi

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AU - Shimada, Akira

AU - Koh, Katsuyoshi

AU - Goto, Hiroaki

AU - Kosaka, Yoshiyuki

AU - Saito, Akiko M.

AU - Horibe, Keizo

AU - Kinoshita, Akitoshi

AU - Tawa, Akio

AU - Taga, Takashi

AU - Adachi, Souichi

AU - Tomizawa, Daisuke

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AB - The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0·011) and low frequency of relapse (P = 0·042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.

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Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Abstract

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ASJC Scopus subject areas

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