Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Takahiro Aoki, Hiroyuki Takahashi, Shiro Tanaka, Norio Shiba, Daiichiro Hasegawa, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, Katsuyoshi Koh, Hiroaki Goto, Yoshiyuki Kosaka, Akiko M. Saito, Keizo Horibe, Akitoshi Kinoshita, Akio Tawa, Takashi Taga, Souichi Adachi, Daisuke Tomizawa

Research output: Contribution to journalArticle

Abstract

The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0·011) and low frequency of relapse (P = 0·042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.

Original languageEnglish
JournalBritish Journal of Haematology
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • acute myeloid leukaemia
  • chemosensitivity
  • children
  • myelosuppression
  • neutropenia

ASJC Scopus subject areas

  • Hematology

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    Aoki, T., Takahashi, H., Tanaka, S., Shiba, N., Hasegawa, D., Iwamoto, S., Terui, K., Moritake, H., Nakayama, H., Shimada, A., Koh, K., Goto, H., Kosaka, Y., Saito, A. M., Horibe, K., Kinoshita, A., Tawa, A., Taga, T., Adachi, S., & Tomizawa, D. (Accepted/In press). Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. British Journal of Haematology. https://doi.org/10.1111/bjh.16656