TY - JOUR
T1 - Predictors of responses to corticosteroids for anorexia in advanced cancer patients
T2 - a multicenter prospective observational study
AU - Matsuo, Naoki
AU - Morita, Tatsuya
AU - Matsuda, Yoshinobu
AU - Okamoto, Kenichiro
AU - Matsumoto, Yoshihisa
AU - Kaneishi, Keisuke
AU - Odagiri, Takuya
AU - Sakurai, Hiroki
AU - Katayama, Hideki
AU - Mori, Ichiro
AU - Yamada, Hirohide
AU - Watanabe, Hiroaki
AU - Yokoyama, Taro
AU - Yamaguchi, Takashi
AU - Nishi, Tomohiro
AU - Shirado, Akemi
AU - Hiramoto, Shuji
AU - Watanabe, Toshio
AU - Kohara, Hiroyuki
AU - Shimoyama, Satofumi
AU - Aruga, Etsuko
AU - Baba, Mika
AU - Sumita, Koki
AU - Iwase, Satoru
N1 - Funding Information:
This research is (partially) supported by the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and Development, AMED.
Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Purpose: Although corticosteroids are widely used to relieve anorexia, information regarding the factors predicting responses to corticosteroids remains limited. The purpose of the study is to identify potential factors predicting responses to corticosteroids for anorexia in advanced cancer patients. Methods: Inclusion criteria for this multicenter prospective observational study were patients who had metastatic or locally advanced cancer and had an anorexia intensity score of 4 or more on a 0–10 Numerical Rating Scale (NRS). Univariate and multivariate analyses were conducted to identify the factors predicting ≥2-point reduction in NRS on day 3. Results: Among 180 patients who received corticosteroids, 99 (55 %; 95 % confidence interval [CI], 47–62 %) had a response with ≥2-point reduction. Factors that significantly predicted responses were Palliative Performance Scale (PPS) > 40 and absence of drowsiness. In addition, factors that tended to be associated with ≥2-point reduction in NRS included PS 0–3, absence of diabetes mellitus, absence of peripheral edema, presence of lung metastasis, absence of peritoneal metastasis, baseline anorexia NRS of >6, presence of pain, and presence of constipation. A multivariate analysis showed that the independent factors predicting responses were PPS of >40 (odds ratio = 2.7 [95 % CI = 1.4–5.2]), absence of drowsiness (2.6 [1.3–5.0]), and baseline NRS of >6 (2.4 [1.1–4.8]). Conclusions: Treatment responses to corticosteroids for anorexia may be predicted by PPS, drowsiness, and baseline symptom intensity. Larger prospective studies are needed to confirm these results.
AB - Purpose: Although corticosteroids are widely used to relieve anorexia, information regarding the factors predicting responses to corticosteroids remains limited. The purpose of the study is to identify potential factors predicting responses to corticosteroids for anorexia in advanced cancer patients. Methods: Inclusion criteria for this multicenter prospective observational study were patients who had metastatic or locally advanced cancer and had an anorexia intensity score of 4 or more on a 0–10 Numerical Rating Scale (NRS). Univariate and multivariate analyses were conducted to identify the factors predicting ≥2-point reduction in NRS on day 3. Results: Among 180 patients who received corticosteroids, 99 (55 %; 95 % confidence interval [CI], 47–62 %) had a response with ≥2-point reduction. Factors that significantly predicted responses were Palliative Performance Scale (PPS) > 40 and absence of drowsiness. In addition, factors that tended to be associated with ≥2-point reduction in NRS included PS 0–3, absence of diabetes mellitus, absence of peripheral edema, presence of lung metastasis, absence of peritoneal metastasis, baseline anorexia NRS of >6, presence of pain, and presence of constipation. A multivariate analysis showed that the independent factors predicting responses were PPS of >40 (odds ratio = 2.7 [95 % CI = 1.4–5.2]), absence of drowsiness (2.6 [1.3–5.0]), and baseline NRS of >6 (2.4 [1.1–4.8]). Conclusions: Treatment responses to corticosteroids for anorexia may be predicted by PPS, drowsiness, and baseline symptom intensity. Larger prospective studies are needed to confirm these results.
KW - Anorexia
KW - Cancer
KW - Corticosteroids
KW - Palliative care
KW - Predictors
UR - http://www.scopus.com/inward/record.url?scp=84982255194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982255194&partnerID=8YFLogxK
U2 - 10.1007/s00520-016-3383-z
DO - 10.1007/s00520-016-3383-z
M3 - Article
C2 - 27539132
AN - SCOPUS:84982255194
VL - 25
SP - 41
EP - 50
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
SN - 0941-4355
IS - 1
ER -