Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C

Yuki Moritou, Fusao Ikeda, Yoshiaki Iwasaki, Nobuyuki Baba, Kouichi Takaguchi, Tomonori Senoh, Takuya Nagano, Yasuto Takeuchi, Tetsuya Yasunaka, Hideki Ohnishi, Yasuhiro Miyake, Akinobu Takaki, Kazuhiro Nouso, Kazuhide Yamamoto

Research output: Contribution to journalArticle

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Abstract

The impact of single-nucleotide polymorphisms (SNP) of patatin-like phospholipase domaincontaining protein 3 (PNPLA3) on development of hepatocellular carcinoma (HCC) is not clarified for Japanese patients with chronic hepatitis C. The present study investigated the associations of rs738409 PNPLA3 with HCC development after the antiviral therapy with peg-interferon and ribavirin for Japanese patients with hepatitis C virus serotype 1 and high viral load. Of the 271 patients enrolled in the study, 20 patients developed HCC, during a median follow-up period of 4.6 years. Multivariate analysis in the proportional hazards models revealed that sex, body mass index, platelet counts, and alpha feroprotein (AFP) had significant associations with HCC development (p = 0.011, 0.029, 0.0002, and 0.046, respectively). Multivariate regression analysis revealed that PNPLA3 148 M was significantly associated with serum AFP level (p = 0.032), other than body mass index, platelet count, and alanine aminotransferase (p = 0.0006, 0.0002, and 0.037, respectively), and that serum AFP level was significantly associated with PNPLA3 148 M (p = 0.017). Serum AFP level is an important factor in predicting HCC development after the antiviral therapy for Japanese patients with chronic hepatitis C, the mechanism of which might involve its significant associations with the SNP genotype of PNPLA3.

Original languageEnglish
JournalSpringerPlus
Volume2
Issue number1
DOIs
Publication statusPublished - 2013

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Phospholipases
Chronic Hepatitis C
Interferons
Hepatocellular Carcinoma
Proteins
Platelet Count
Antiviral Agents
Single Nucleotide Polymorphism
Body Mass Index
Multivariate Analysis
Serum
Therapeutics
Ribavirin
Viral Load
Alanine Transaminase
Proportional Hazards Models
Hepacivirus
Genotype
Regression Analysis

Keywords

  • HCC
  • HCV
  • Interferon
  • PNPLA3

ASJC Scopus subject areas

  • General

Cite this

Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C. / Moritou, Yuki; Ikeda, Fusao; Iwasaki, Yoshiaki; Baba, Nobuyuki; Takaguchi, Kouichi; Senoh, Tomonori; Nagano, Takuya; Takeuchi, Yasuto; Yasunaka, Tetsuya; Ohnishi, Hideki; Miyake, Yasuhiro; Takaki, Akinobu; Nouso, Kazuhiro; Yamamoto, Kazuhide.

In: SpringerPlus, Vol. 2, No. 1, 2013.

Research output: Contribution to journalArticle

Moritou, Yuki ; Ikeda, Fusao ; Iwasaki, Yoshiaki ; Baba, Nobuyuki ; Takaguchi, Kouichi ; Senoh, Tomonori ; Nagano, Takuya ; Takeuchi, Yasuto ; Yasunaka, Tetsuya ; Ohnishi, Hideki ; Miyake, Yasuhiro ; Takaki, Akinobu ; Nouso, Kazuhiro ; Yamamoto, Kazuhide. / Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C. In: SpringerPlus. 2013 ; Vol. 2, No. 1.
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abstract = "The impact of single-nucleotide polymorphisms (SNP) of patatin-like phospholipase domaincontaining protein 3 (PNPLA3) on development of hepatocellular carcinoma (HCC) is not clarified for Japanese patients with chronic hepatitis C. The present study investigated the associations of rs738409 PNPLA3 with HCC development after the antiviral therapy with peg-interferon and ribavirin for Japanese patients with hepatitis C virus serotype 1 and high viral load. Of the 271 patients enrolled in the study, 20 patients developed HCC, during a median follow-up period of 4.6 years. Multivariate analysis in the proportional hazards models revealed that sex, body mass index, platelet counts, and alpha feroprotein (AFP) had significant associations with HCC development (p = 0.011, 0.029, 0.0002, and 0.046, respectively). Multivariate regression analysis revealed that PNPLA3 148 M was significantly associated with serum AFP level (p = 0.032), other than body mass index, platelet count, and alanine aminotransferase (p = 0.0006, 0.0002, and 0.037, respectively), and that serum AFP level was significantly associated with PNPLA3 148 M (p = 0.017). Serum AFP level is an important factor in predicting HCC development after the antiviral therapy for Japanese patients with chronic hepatitis C, the mechanism of which might involve its significant associations with the SNP genotype of PNPLA3.",
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AU - Moritou, Yuki

AU - Ikeda, Fusao

AU - Iwasaki, Yoshiaki

AU - Baba, Nobuyuki

AU - Takaguchi, Kouichi

AU - Senoh, Tomonori

AU - Nagano, Takuya

AU - Takeuchi, Yasuto

AU - Yasunaka, Tetsuya

AU - Ohnishi, Hideki

AU - Miyake, Yasuhiro

AU - Takaki, Akinobu

AU - Nouso, Kazuhiro

AU - Yamamoto, Kazuhide

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