Predictive factors of efficacy of leukocytapheresis for steroid-resistant ulcerative colitis patients

K. Takemoto, J. Kato, M. Kuriyama, T. Nawa, M. Kurome, Hiroyuki Okada, K. Sakaguchi, Y. Shiratori

Research output: Contribution to journalArticle

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Abstract

Background: The effectiveness of leukocytapheresis against ulcerative colitis has been reported. However, the efficacy of this therapy for steroid-resistant ulcerative colitis patients has hardly been examined. Aims: The aims of this study are to evaluate the efficacy of leukocytapheresis for steroid-resistant ulcerative colitis patients and to identify clinical factors that predict the efficacy of this therapy for these patients. Methods: Clinical factors of 71 steroid-resistant ulcerative colitis patients who underwent leukocytapheresis analysed. Results: Of those analysed, 53 (75%) patients showed an initial response to leukocytapheresis. Among cases with initial response, however, only 19 (27%) patients maintained remission for more than 6 months. Steroid-dependent course (Odds ratio = 5.53, 95% confidence interval; 1.24-24.73) and a high C-reactive protein degree (Odds ratio = 1.6, confidence interval; 1.09-2.35) were predictors of initial response to leukocytapheresis. Rapid response, which means remission induction within three leukocytapheresis sessions, was the only predictor of maintenance of remission for more than 6 months after successful leukocytapheresis therapy (odds ratio = 8.01, confidence interval; 1.08-59.37). Conclusions: Leukocytapheresis was effective for steroid-resistant ulcerative colitis patients. However, relapse was frequently observed within short periods after the initial response to this therapy. Patients without a rapid response should be treated with alternative or additional therapies.

Original languageEnglish
Pages (from-to)422-429
Number of pages8
JournalDigestive and Liver Disease
Volume39
Issue number5
DOIs
Publication statusPublished - May 2007

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Leukapheresis
Ulcerative Colitis
Steroids
Odds Ratio
Confidence Intervals
Therapeutics
Remission Induction
C-Reactive Protein
Maintenance
Recurrence

Keywords

  • Leukocytapheresis
  • Steroid-resistant ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Predictive factors of efficacy of leukocytapheresis for steroid-resistant ulcerative colitis patients. / Takemoto, K.; Kato, J.; Kuriyama, M.; Nawa, T.; Kurome, M.; Okada, Hiroyuki; Sakaguchi, K.; Shiratori, Y.

In: Digestive and Liver Disease, Vol. 39, No. 5, 05.2007, p. 422-429.

Research output: Contribution to journalArticle

Takemoto, K, Kato, J, Kuriyama, M, Nawa, T, Kurome, M, Okada, H, Sakaguchi, K & Shiratori, Y 2007, 'Predictive factors of efficacy of leukocytapheresis for steroid-resistant ulcerative colitis patients', Digestive and Liver Disease, vol. 39, no. 5, pp. 422-429. https://doi.org/10.1016/j.dld.2007.01.010
Takemoto, K. ; Kato, J. ; Kuriyama, M. ; Nawa, T. ; Kurome, M. ; Okada, Hiroyuki ; Sakaguchi, K. ; Shiratori, Y. / Predictive factors of efficacy of leukocytapheresis for steroid-resistant ulcerative colitis patients. In: Digestive and Liver Disease. 2007 ; Vol. 39, No. 5. pp. 422-429.
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