TY - JOUR
T1 - Predicting pleural invasion using HRCT and 18F-FDG PET/CT in lung adenocarcinoma with pleural contact
AU - Tanaka, Takashi
AU - Shinya, Takayoshi
AU - Sato, Shuhei
AU - Mitsuhashi, Toshiharu
AU - Ichimura, Koichi
AU - Sou, Junichi
AU - Toyooka, Shinichi
AU - Kaji, Mitsumasa
AU - Miyoshi, Shinichiro
AU - Kanazawa, Susumu
N1 - Publisher Copyright:
© 2015, The Japanese Society of Nuclear Medicine.
PY - 2015/7/5
Y1 - 2015/7/5
N2 - Objective: To evaluate the relevance of high-resolution computed tomography (HRCT) findings and fluorine-18-fluorodeoxyglucose (18F-FDG) uptake for risk stratification of visceral pleural invasion by lung adenocarcinoma. Methods: The HRCT findings and 18F-FDG uptake for lung adenocarcinomas with pleural contact on CT were retrospectively analyzed in 208 consecutive patients (94 females and 114 males; median age, 69.0 years) between January 2009 and December 2013, with institutional review board approval. The HRCT findings and maximum standardized uptake value (SUVmax) were recorded for each patient. Multivariate logistic regression was used for statistical analysis, and subgroup analysis stratified for whole tumor size ≤3 cm was also performed. Results: Multivariate analysis showed that SUVmax [odds ratio (OR) 1.09, 95 % confidence interval (CI) 1.02–1.16, P = 0.014] and obtuse angle (OR 4.14, 95 % CI 1.97–8.74, P < 0.001) were significant independent predictors for visceral pleural invasion. Receiver operating characteristic (ROC) analysis showed that, compared with the multivariate models [area under the curve (Az) 0.819–0.829], SUVmax alone (Az 0.815) was useful in predicting visceral pleural invasion. In the subgroup analysis, multivariate analysis showed that SUVmax (OR 1.29, 95 % CI 1.12–1.50, P = 0.001) and contact length with the pleura (OR 1.13, 95 % CI 1.05–1.22, P = 0.001) were significant independent predictors for visceral pleural invasion. ROC analysis showed that SUVmax alone (Az 0.844) showed similar diagnostic performance to the multivariate models (Az 0.845–0.857). Conclusions: SUVmax alone and multivariate models including SUVmax are useful for the prediction of visceral pleural invasion by lung adenocarcinoma.
AB - Objective: To evaluate the relevance of high-resolution computed tomography (HRCT) findings and fluorine-18-fluorodeoxyglucose (18F-FDG) uptake for risk stratification of visceral pleural invasion by lung adenocarcinoma. Methods: The HRCT findings and 18F-FDG uptake for lung adenocarcinomas with pleural contact on CT were retrospectively analyzed in 208 consecutive patients (94 females and 114 males; median age, 69.0 years) between January 2009 and December 2013, with institutional review board approval. The HRCT findings and maximum standardized uptake value (SUVmax) were recorded for each patient. Multivariate logistic regression was used for statistical analysis, and subgroup analysis stratified for whole tumor size ≤3 cm was also performed. Results: Multivariate analysis showed that SUVmax [odds ratio (OR) 1.09, 95 % confidence interval (CI) 1.02–1.16, P = 0.014] and obtuse angle (OR 4.14, 95 % CI 1.97–8.74, P < 0.001) were significant independent predictors for visceral pleural invasion. Receiver operating characteristic (ROC) analysis showed that, compared with the multivariate models [area under the curve (Az) 0.819–0.829], SUVmax alone (Az 0.815) was useful in predicting visceral pleural invasion. In the subgroup analysis, multivariate analysis showed that SUVmax (OR 1.29, 95 % CI 1.12–1.50, P = 0.001) and contact length with the pleura (OR 1.13, 95 % CI 1.05–1.22, P = 0.001) were significant independent predictors for visceral pleural invasion. ROC analysis showed that SUVmax alone (Az 0.844) showed similar diagnostic performance to the multivariate models (Az 0.845–0.857). Conclusions: SUVmax alone and multivariate models including SUVmax are useful for the prediction of visceral pleural invasion by lung adenocarcinoma.
KW - F-FDG
KW - HRCT
KW - Lung adenocarcinoma
KW - PET/CT
KW - Visceral pleural invasion
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U2 - 10.1007/s12149-015-0999-x
DO - 10.1007/s12149-015-0999-x
M3 - Article
C2 - 26142739
AN - SCOPUS:84945481285
VL - 29
SP - 757
EP - 765
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
SN - 0914-7187
IS - 9
ER -