Predictability of O2 consumption from contractility and mechanical energy of absolute arrhythmic beats in canine heart

Juichiro Shimizu, Satoshi Mohri, Gentaro Iribe, Haruo Ito, Terumasa Morita, Hiroki Yamaguchi, Shunji Sano, Hiroyuki Suga

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Left ventricular (LV) O2 consumption (VO2) per minute is measurable for both regular and arrhythmic beats. LV VO2 per beat can then be obtained as VO2 per minute divided by heart rate per minute for regular beats, but not for arrhythmic beats. We have established that VO2 of a regular stable beat is predictable by VO2 = a PVA + b Emax + c, where PVA is the systolic pressure-volume area as a measure of the total mechanical energy of an individual contraction and E max is the end-systolic maximum elastance as an index of ventricular contractility of the contraction. Furthermore, a is the O2 cost of PVA, b is the O2 cost of Emax, and c is the basal metabolic VO2 per beat. We considered it theoretically reasonable to expect that the same formula could also predict LV VO2 of individual arrhythmic beats from their respective PVA and Emax with the same a, b, and c. We therefore applied this formula to the PVA - Emax data of individual arrhythmic beats under electrically induced atrial fibrillation (AF) in six canine in situ hearts. We found that the predicted VO2 of individual arrhythmic beats highly correlated linearly with either their VO 2 (r = 0.96 ± 0.01) or Emax (0.97 ± 0.03) while both also highly correlated linearly with each other (0.88 ± 0.04). This suggests that the above formula may be used to predict LV VO2 of absolute arrhythmic beats from their Emax and PVA under AF.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalJapanese Journal of Physiology
Volume55
Issue number2
DOIs
Publication statusPublished - Apr 2005

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Atrial Fibrillation
Canidae
Costs and Cost Analysis
Heart Rate
Blood Pressure

Keywords

  • Arrhythmia
  • Cardiac function
  • Mechanoenergetics
  • Oxygen consumption

ASJC Scopus subject areas

  • Physiology

Cite this

Predictability of O2 consumption from contractility and mechanical energy of absolute arrhythmic beats in canine heart. / Shimizu, Juichiro; Mohri, Satoshi; Iribe, Gentaro; Ito, Haruo; Morita, Terumasa; Yamaguchi, Hiroki; Sano, Shunji; Suga, Hiroyuki.

In: Japanese Journal of Physiology, Vol. 55, No. 2, 04.2005, p. 135-142.

Research output: Contribution to journalArticle

Shimizu, Juichiro ; Mohri, Satoshi ; Iribe, Gentaro ; Ito, Haruo ; Morita, Terumasa ; Yamaguchi, Hiroki ; Sano, Shunji ; Suga, Hiroyuki. / Predictability of O2 consumption from contractility and mechanical energy of absolute arrhythmic beats in canine heart. In: Japanese Journal of Physiology. 2005 ; Vol. 55, No. 2. pp. 135-142.
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